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[1]楊輝,張東元,張青鈴,等.葛明膠囊防潮輔料的優(yōu)選研究[J].福建醫(yī)藥雜志,2022,44(02):119-123.
　YANG Hui,ZHANG Dongyuan,ZHANG Qingling,et al.Study on optimum selection of moisture-proof excipients for Geming Capsules[J].FUJIAN MEDICAL JOURNAL,2022,44(02):119-123.
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葛明膠囊防潮輔料的優(yōu)選研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年02期
頁(yè)碼:
119-123
欄目:
基礎(chǔ)研究
出版日期:
2022-04-15

文章信息/Info

Title:
Study on optimum selection of moisture-proof excipients for Geming Capsules
文章編號(hào):
1002-2600(2022)02-0119-05
作者:
楊輝; 張東元1; 張青鈴1; 羅友華2; 劉曉娟; 許光輝; 黃亦琦
廈門市健康醫(yī)療大數(shù)據(jù)中心 廈門市醫(yī)藥研究所 廈門市天然藥物研究與開(kāi)發(fā)重點(diǎn)實(shí)驗(yàn)室(廈門 361008)
Author(s):
YANG Hui;  ZHANG Dongyuan;  ZHANG Qingling;  LUO Youhua;  LIU Xiaojuan;  XU Guanghui;  HUANG Yiqi
Xiamen Key Laboratory of Natural Medicine Research and Development, Xiamen Medicine Institute, Xiamen Health and Medical Big Data Center, Xiamen, Fujian 361008, China
關(guān)鍵詞:
葛明膠囊;  防潮輔料;  優(yōu)選;  吸濕動(dòng)力學(xué)曲線;  吸濕等溫曲線下面積
Keywords:
Geming Capsules;  moisture-proof excipients;  optimize;  hygroscopic dynamics curve;  area under the hygroscopic isothermal curve
分類號(hào):
R944
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 優(yōu)選葛明膠囊的防潮輔料。方法 以稱重法測(cè)定含輔料葛明膠囊浸膏粉(HFLJGF)在25 ℃ 不同相對(duì)濕度(RH)下120 h內(nèi)每隔24 h的含水率。應(yīng)用orignPro8軟件,以殘差平方和(RSS)、相關(guān)系數(shù)(R2)、赤池信息準(zhǔn)則(AIC)為指標(biāo),優(yōu)選HFLJGF吸濕等溫和吸濕動(dòng)力學(xué)曲線模型; 以吸濕等溫曲線下面積(AUHIC)優(yōu)選葛明膠囊的防潮輔料。結(jié)果 18種HFLJGF在不同RH下放120 h的含水率為0.17%～47.52%。HFLJGF的最優(yōu)吸濕動(dòng)力學(xué)曲線為SWeibull2和雙指數(shù)模型,吸濕等溫曲線均為Peleg模型。18個(gè)HFLJGF中,AUHIC最小的防潮輔料為山崳酸甘油酯。結(jié)論 葛明膠囊的最優(yōu)防潮輔料為山崳酸甘油酯,AUHIC可數(shù)字化表征和定量評(píng)價(jià)藥物吸濕性強(qiáng)弱,為中藥制劑防潮輔料優(yōu)選提供參考。
Abstract:
Objective To optimize the moisture-proof excipients of Geming Capsules.Methods The moisture content of Geming Capsules extract powder with excipient(HFLJGF)was determined by weighing method at intervals of 24 h within 120 h at different relative humidity(RH)under 25 ℃.OrignPro8 software was used to optimize the models of the hygroscopic isothermal curve and the hygroscopic dynamics curve of Geming Capsules extract powder with expipients(HFLJGF), taking the sum of residual squares(RSS), the correlation coefficient(R2)and the akaike information criterion(AIC)as indicators.The area under the hygroscopic isothermal curve(AUHIC)was used to select the moisture-proof auxiliary material for Geming capsules.Results The moisture content of 18 kinds of HFLJGF under the different RH for 120 h ranged from 0.17% to 47.52%.The optimal mathematical model of hygroscopic dynamics curve of HFLJGF was SWeibull2 or double exponential model, and the hygroscopic isothermal curve was Peleg model.In the 18 HFLJGF,the smallest moisture-proof excipient of AUHIC was glyceryl behenate.Conclusion Glyceryl behenate is the best moisture proof excipient for Geming Capsules, and AUHIC can digitally characterize and evaluate the hygroscopicity of drugs, providing reference for the selection of moisture-proof excicients for traditional Chinese medicine preparations.

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備注/Memo

備注/Memo:
基金項(xiàng)目:廈門市醫(yī)療衛(wèi)生指導(dǎo)性項(xiàng)目(3502Z20209258)
1 福建中醫(yī)藥大學(xué)藥學(xué)院; 2 通信作者:Email:[email protected]
更新日期/Last Update: 2022-04-15