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[1]伍林招,張韜,劉熹陽,等.乙醇胺改性聚己內(nèi)酯制備親水性組織工程支架的研究[J].福建醫(yī)藥雜志,2022,44(02):114-116.
　WU Linzhao,ZHANG Tao,LIU Yan,et al.Preparation of hydrophilic tissue engineering scaffold by modified polycaprolactone with ethanolamine[J].FUJIAN MEDICAL JOURNAL,2022,44(02):114-116.
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乙醇胺改性聚己內(nèi)酯制備親水性組織工程支架的研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年02期
頁碼:
114-116
欄目:
基礎(chǔ)研究
出版日期:
2022-04-15

文章信息/Info

Title:
Preparation of hydrophilic tissue engineering scaffold by modified polycaprolactone with ethanolamine
文章編號:
1002-2600(2022)02-0114-03
作者:
伍林招; 張韜1; 劉熹陽; 劉巖; 劉楠楠
廈門大學(xué)附屬福州第二醫(yī)院骨科研究所(福州 350001)
Author(s):
WU Linzhao;  ZHANG Tao;  LIU Yan;  LIU Nannan
Department of Orthopedics Institute, the Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
組織工程;  組織修復(fù);  支架
Keywords:
tissue engineering;  tissue repair;  scaffold
分類號:
R318
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 探討聚己內(nèi)酯材料親水性能增強的改性方法及工藝條件,制備有利于細(xì)胞黏附的親水性組織工程支架。方法 通過堿性乙醇胺與聚己內(nèi)酯間發(fā)生氨解反應(yīng)形成酰胺鍵,在聚己內(nèi)酯表面接枝親水性的氨基和羥基,改善其親水性能。在-80 ℃凝膠化相分離制備類細(xì)胞外基質(zhì)的納米纖維組織工程支架。結(jié)果 掃描電子顯微鏡(SEM)圖顯示支架呈多孔狀結(jié)構(gòu),支架的親水性能增強。結(jié)論 當(dāng)凝膠化為-80 ℃時,類似于細(xì)胞外基質(zhì)的納米纖維狀組織工程支架形成,支架孔隙率均大于80%,改性劑濃度增大支架的親水性增強。
Abstract:
Objective The modification methods and technological conditions of polycaprolactone material with enhanced hydrophilicity were investigated to prepare tissue engineering scaffolds which were beneficial to cell adhesion and growth.Methods The hydrophilic properties of polycaprolactone were improved by grafting hydrophilic amino and hydroxyl groups on the surface of polycaprolactone, which was formed by ammonolysis reaction between ethanolamine and polycaprolactone.The extracellular matrix-like nanofiber tissue engineering scaffolds were prepared by gel phase separation at -80 ℃.Results SEM image showed that the scaffold had a porous structure, and the hydrophilicity of scaffold was enhanced.Conclusion When gelated at -80 ℃, nanofibrous tissue engineering scaffolds similar to extracellular matrix were formed,and the porosity of scaffolds was more than 80%.With the increase of modifier concentration, the hydrophilicity of scaffolds was enhanced.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項目:2020年福州市衛(wèi)生健康科技創(chuàng)新平臺建設(shè)項目(2020-S-wp3)
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更新日期/Last Update: 2022-04-15