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[1]張璇,章斌斌,陳仔穎.基于“3A學(xué)說”探討逐瘀湯對(duì)子宮內(nèi)膜異位癥大鼠VEGF表達(dá)的影響[J].福建醫(yī)藥雜志,2022,44(01):1-4.
　ZHANG Xuan,ZHANG Binbin,CHEN Zaiying.Effect of Zhuyu decoction on the VEGF levels of rats with endometriosis based on the 3A theory[J].FUJIAN MEDICAL JOURNAL,2022,44(01):1-4.
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基于“3A學(xué)說”探討逐瘀湯對(duì)子宮內(nèi)膜異位癥大鼠VEGF表達(dá)的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年01期
頁(yè)碼:
1-4
欄目:
臨床研究
出版日期:
2022-02-15

文章信息/Info

Title:
Effect of Zhuyu decoction on the VEGF levels of rats with endometriosis based on the 3A theory
文章編號(hào):
1002-2600(2022)01-0001-04
作者:
張璇; 章斌斌; 陳仔穎
福建中醫(yī)藥大學(xué)附屬人民醫(yī)院(福州350004)
Author(s):
ZHANG Xuan;  ZHANG Binbin;  CHEN Zaiying
The Affiliated People's Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350004, China
關(guān)鍵詞:
逐瘀湯; 子宮內(nèi)膜異位癥大鼠; VEGF
Keywords:
Zhuyu decoction;  endometriosis;  VEGF
分類號(hào):
R711.71
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 基于“3A學(xué)說”探討逐瘀湯對(duì)子宮內(nèi)膜異位癥(EMS)大鼠VEGF的影響。方法 采用自體移植方法建立EMS模型，將建模成功的大鼠采用隨機(jī)數(shù)字表法分為對(duì)照組、米非司酮組及逐瘀湯組，選取正常飼養(yǎng)SD大鼠作為假手術(shù)組，每組20只。采用ELISA法檢測(cè)各組大鼠治療前、治療后血清VEGF水平;采用Western blot法檢測(cè)各組腹腔移植物組織VEGF蛋白表達(dá)情況;采用RT-PCR法檢測(cè)各組腹腔移植物組織VEGF mRNA表達(dá)情況。結(jié)果 1)治療前與假手術(shù)組比較，其他3組大鼠血清中VEGF水平顯著升高(P<0.05); 治療后，米非司酮組、逐瘀湯組大鼠血清中VEGF水平較對(duì)照組顯著降低(P<0.05);米非司酮組與逐瘀湯組大鼠血清VEGF水平比較，差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。 2)治療后米非司酮組與逐瘀湯組大鼠腹腔移植物組織VEGF蛋白表達(dá)較對(duì)照組明顯降低(P<0.05)，米非司酮組與逐瘀湯組表達(dá)差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。 3)治療后，與對(duì)照組相比，米非司酮組和逐瘀湯組大鼠異位內(nèi)膜組織VEGF mRNA表達(dá)水平均明顯降低(P<0.05), 米非司酮組與逐瘀湯組表達(dá)差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論 逐瘀湯 能降低EMT大鼠血清中VEGF水平，可以減輕異位內(nèi)膜組織中VEGF蛋白及mRNA的表達(dá)。
Abstract:
Objective To explore the effect of Zhuyu decoction on the VEGF levels in rats with endometriosis based on the 3A theory. Methods By autologous transplantation, the EMS rats models were successfully established. These models were randomly divided into model control group, mifepristone group and Zhuyu decoction group through method of random number table. Normal feeding SD rats were selected as sham operation group. Each group included 20 rats. The serum levels of VEGF of each group were tested through ELISA before and after treatment. The levels of VEGF expression in endometriosis were detected by Western blot. And the level of VEGF expression in ectopic tissues were detected by Fluorescence quantitative PCR. Results ①Compared with the sham operation group, the serum levels of VEGF in other groups were significantly increased before treatment (P<0. 05). After treatment, the serum levels of VEGF in the mifepristone group and the Zhuyu decoction group were significantly lower, compared with the model control group (P<0.05). There was no significant difference in the serum level of VEGF between the mifepristone group and the Zhuyu Decoction group (P>0.05).②After treatment, the protein expression of VEGF in the abdominal graft tissue in the mifepristone group and the Zhuyu decoction group was lower than that in the control group (P<0.05)，and the protein expression of mifepristone group and Zhuyu decoction group was not significantly different (P>0.05).③After treatment, the serum level of VEGF gene expression in the mifepristone group and the Zhuyu decoction group was lower than that in the control group (P<0.05)，there was no significant difference in the serum level of VEGF gene expression bet ween the mifepristone group and the Zhuyu decoction group (P>0.05). Conclusion Zhuyu decoction can reduce the serum VEGF of rats with endometriosis, thus reduce the protein and mRNA expression of VEGF.

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相似文獻(xiàn)/References:

[1]張璇 王小紅 林妍 吳小玲.逐瘀湯對(duì)血瘀型子宮內(nèi)膜異位癥性不孕的療效觀察[J].福建醫(yī)藥雜志,2017,39(5):101.

備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金資助項(xiàng)目(2018J01332)
更新日期/Last Update: 2022-02-15