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[1]林潔,郭慈仁,陳雪燕,等.P16蛋白和Ki-67抗原在宮頸上皮內(nèi)瘤變分級診斷中的價值[J].福建醫(yī)藥雜志,2021,43(06):16-17.
 LIN Jie,GUO Ciren,CHEN Xueyan,et al.Significance of P16 protein and Ki-67 antigen in diagnosis of cervical intraepithelial neoplasia[J].FUJIAN MEDICAL JOURNAL,2021,43(06):16-17.
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P16蛋白和Ki-67抗原在宮頸上皮內(nèi)瘤變分級診斷中的價值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年06期
頁碼:
16-17
欄目:
臨床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Significance of P16 protein and Ki-67 antigen in diagnosis of cervical intraepithelial neoplasia
文章編號:
1002-2600(2021)06-0016-02
作者:
林潔郭慈仁1陳雪燕2林杰祥3劉彬陳桂林江信燕
福建省腫瘤醫(yī)院 福建醫(yī)科大學(xué)附屬腫瘤醫(yī)院婦科(福州 350014)
Author(s):
LIN Jie GUO Ciren CHEN Xueyan LIN Jiexiang LIU Bin CHEN Guilin JIANG Xinyan
Department of Tumor Gynaecology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou,Fujian 350014,China
關(guān)鍵詞:
P16 Ki-67 宮頸低級別上皮內(nèi)瘤變 宮頸高級別上皮內(nèi)瘤變 慢性宮頸炎
Keywords:
P16 Ki-67 low-grade cervical intraepithelial neoplasia high-grade cervical intraepithelial neoplasia chronic cervicitis
分類號:
R711.32; R711.7
文獻標(biāo)志碼:
B
摘要:
目的 探討P16蛋白和Ki-67抗原在宮頸上皮內(nèi)瘤變分級診斷中的價值。方法 選擇2019年1月至2021年1月我院診治的50例慢性宮頸炎患者、80例宮頸低級別上皮內(nèi)瘤變患者和80例宮頸高級別上皮內(nèi)瘤變患者為研究對象,采用免疫組化法檢測各組宮頸組織中P16蛋白和Ki-67抗原的表達情況,并對結(jié)果進行統(tǒng)計學(xué)分析。結(jié)果 P16蛋白和Ki-67抗原陽性表達率,宮頸高級別上皮內(nèi)瘤變患者明顯高于低級別上皮內(nèi)瘤變患者(P<0.05); P16蛋白和Ki-67抗原的表達,宮頸上皮內(nèi)瘤變患者均高于慢性宮頸炎患者(P<0.05)。結(jié)論 P16蛋白和Ki-67抗原可作為宮頸上皮內(nèi)瘤變分層管理的重要判斷指標(biāo)。
Abstract:
Objective To investigate the value of P16 and Ki-67 proteins in diagnosis of cervical intraepithelial neoplasia.Methods From January 2019 to January 2021,50 patients with chronic cervicitis, 80 patients with low-grade cervical intraepithelial neoplasia and 80 patients with high-grade cervical intraepithelial neoplasia were selected as research objects.Immunohistochemical method was used to detect the expression of P16 and Ki-67 in three groups and the results were statistically analyzed.Results The positive expression rates of P16 and Ki-67 in patients with high-grade cervical intraepithelial neoplasia were significantly higher than those in patients with low-grade cervical intraepithelial neoplasia(P<0.05); the positive expression rates of P16 and Ki-67 in patients with cervical intraepithelial neoplasia were significantly higher than those in patients with chronic cervicitis(P<0.05).Conclusion P16 and Ki-67 have a good diagnostic value for cervical intraepithelial neoplasia.

參考文獻/References:

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備注/Memo

備注/Memo:
1 通信作者,Email:[email protected]; 2 病理科; 3 福建省立醫(yī)院泌尿外科
更新日期/Last Update: 2021-12-15