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[1]鄭麗靜,林貴山,陳靜波,等.惡性腫瘤患者274例免疫相關(guān)性肺炎的發(fā)生率及影響因素分析[J].福建醫(yī)藥雜志,2021,43(06):5-8.
 ZHENG Lijing,LIN Guishan,CHEN Jingbo,et al.Analysis of incidence and influencing factors of checkpoint inhibitor pneumonitis in 274 patients with malignant tumor[J].FUJIAN MEDICAL JOURNAL,2021,43(06):5-8.
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惡性腫瘤患者274例免疫相關(guān)性肺炎的發(fā)生率及影響因素分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年06期
頁(yè)碼:
5-8
欄目:
臨床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Analysis of incidence and influencing factors of checkpoint inhibitor pneumonitis in 274 patients with malignant tumor
文章編號(hào):
1002-2600(2021)06-0005-04
作者:
鄭麗靜林貴山陳靜波蔣桂成崔同建1
福建省立醫(yī)院腫瘤內(nèi)科(福州 350001)
Author(s):
ZHENG Lijing LIN Guishan CHEN Jingbo JIANG Guicheng CUI Tongjian
Department of Medical Oncology, Fujian Provincial Hospital,Fuzhou,Fujian 350001,China
關(guān)鍵詞:
免疫相關(guān)性肺炎 全身免疫炎癥指數(shù) 胸部放療
Keywords:
checkpoint inhibitor pneumonitis systemic immune-inflammation index thoracic radiotherapy
分類號(hào):
R730
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討免疫相關(guān)性肺炎(CIP)的影響因素。方法 回顧性分析2019年9月至2020年9月接受PD-1/PD-L1治療的274例惡性腫瘤患者,收集患者人口學(xué)特征及臨床資料,計(jì)算SII值。采用單因素和多因素logistic回歸方法分析系統(tǒng)性免疫炎癥指數(shù)(SII)及胸部放療史與CIP的相關(guān)性,應(yīng)用受試者工作曲線(ROC)和曲線下面積(AUC)評(píng)價(jià)免疫治療前SII對(duì)免疫相關(guān)性肺炎發(fā)生的預(yù)測(cè)價(jià)值。結(jié)果 274例免疫檢查點(diǎn)抑制劑(ICIs)治療患者中有胸部放療史25例,發(fā)生CIP的17例。單因素分析顯示,CIP組患者胸部放療史比例明顯高于未發(fā)生CIP組[58.8% vs 5.8%; OR 0.051; CI(0.017,0.159); P<0.001],且CIP組患者免疫治療前SII高于未發(fā)生CIP組患者,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。ROC曲線分析顯示,SII 預(yù)測(cè)ICIs治療發(fā)生免疫相關(guān)性肺炎的AUC值為 0.739(P<0.001),SII值為1 139.82時(shí)預(yù)測(cè)價(jià)值最高,其發(fā)生CIP的敏感度為 64.7%,特異度為 77.0%。結(jié)論 SII及胸部放療史是ICIs治療患者發(fā)生CIP的影響因素。
Abstract:
Objective To investigate the influencing factors of checkpoint inhibitor pneumonitis(CIP).Methods A retrospective analysis of 274 patients with malignant tumors who received PD-1/PD-L1 treatment was performed.The demographic characteristics and clinical data of the patients were collected and the SII value was calculated.Univariate and multivariate logistic regression methods were used to analyze the correlation between SII,thoracic radiotherapy history and CIP.Receiver operating curve(ROC)and area under the curve(AUC)were used to evaluate the predictive value of SII to CIP.Results Of the 274 patients, 25 had a history of chest radiotherapy, and 17 had CIP.Univariate analysis showed that the rate of patients with thoracic radiotherapy in the CIP group was significantly higher than that in the non-CIP group [58.8% vs 5.8%; OR 0.051; CI(0.017,0.159); P<0.001], and SII in the CIP group was higher than that in the non-CIP group, with statistical significance(P<0.05).The ROC curve analysis showed that the area under the curve of SII was 0.739(P<0.001).The cut-off value for predicting CIP was 1 139.82,the sensitivity and specificity was 64.7% and 77.0%.Conclusion SII and thoracic radiotherapy were independent risk factors to predict CIP in patients treated with ICIs.

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備注/Memo

備注/Memo:
1 通信作者,Email:[email protected]
更新日期/Last Update: 2021-12-15