參考文獻/References:
[1] Monory K,Blaudzun H,Massa F,et al.Genetic dissection of behavioural and autonomic effects of Δ9-tetrahydrocannabinol in mice[J].PLoS Biol,2007,5(10):e269.[2] Munro S,Thomas K L,Abu-Shaar M.Molecular characterization of a peripheral receptor for cannabinoids [J].Nature,1993,365(6441):61-65.[3] Salazar A I,Carozzo A,Correa F,et al.Evidence for CB2 receptor involvement in LPS-induced reduction of cAMP intracellular levels in uterine explants from pregnant mice:pathophysiological implications[J].Mol Hum Reprod,2017,23(7):500-508.[4] Herrera B,Carracedo A,Diez-Zaera M,et al.p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells[J].FEBS Lett,2005,579(22):5084-5088.[5] Romero-Sandoval E A,Horvath R,Landry R P,et al.Cannabinoid receptor type 2 activation induces a microglial anti-in ammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation[J].Mol Pain,2009,5:25.[6] den Boon F S,Chameau P,Schaafsma-Zhao Q,et al.Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors[J].Proc Natl Acad Sci U S A,2012,109(9):3534-3539.[7] Berger N D,Gadotti V M,Petrov R R.NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors[J].Mol Pain,2014,10:77.[8] Van Sickle M D,Duncan M,Kingsley P J,et al.Identi cation and functional characterization of brainstem cannabinoid CB2 receptors[J].Science,2005,310(5746):329-332.[9] Gong J P,Onaivi E S,Ishiguro H,et al.Cannabinoid CB2 receptors:immunohistochemical localization in rat brain[J].Brain Res,2006,1071(1):10-23.[10] Maresz K,Carrier E J,Ponomarev E D,et al.Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli[J].J Neurochem,2005,95(2):437-445.[11] Ibrahim M M,Rude M L,Stagg N J,et al.CB2 cannabinoid receptor mediation of antinociception[J].Pain,2006,122(1-2):36-42.[12] Ke P,Shao B Z,Xu Z Q,et al.Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through inhibiting NLRP3 inflammasome in Macrophages[J].PloS One,2016,11(9):e0155076.[13] Bujalska-Zadro(·overz)ny M,de Cordé A,Pawlik K.Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy[J].Pharmacol Rep,2015,67(2):209-216.[14] Ji D X,Liang Z Y,Liu G X,et al.Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer[J].Naunyn Schmiedebergs Arch Pharmacol,2017,390(12):1211-1219.[15] Watkins L R,Milligan E D,Maier S F.Glial proinflammatory cytokines mediate exaggerated pain states:implications for clinical pain[J].Adv Exp Med Biol,2003,521:1-21.[16] Gao Y J,Ji R R,Chemokines,neuronal-glial interactions,and central processing of neuropathic pain[J].Pharmacol Ther,2010,126(1):56-68.[17] Li X T,Hua T,Vemuri K,et al.Crystal structure of the human cannabinoid receptor CB2[J].Cell,2019,176(3):459-467.