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[1]鄭文通,張洪彬,鐘國(guó)偉,等.全面檢測(cè)Y染色體AZF微缺失方法的研究[J].福建醫(yī)藥雜志,2021,43(05):23-27.
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全面檢測(cè)Y染色體AZF微缺失方法的研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年05期
頁(yè)碼:
23-27
欄目:
臨床研究
出版日期:
2021-10-15

文章信息/Info

文章編號(hào):
1002-2600(2021)05-0023-05
作者:
鄭文通張洪彬鐘國(guó)偉闕華星袁建興張滿娥彭明健1
福建省龍巖市第二醫(yī)院(龍巖 364000)
關(guān)鍵詞:
Y染色體AZF微缺失 全面檢測(cè) 探針捕獲體系 二代測(cè)序
分類號(hào):
R698+.2
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 研究全面檢測(cè)Y染色體AZF微缺失的方法。方法 用自主設(shè)計(jì)探針捕獲體系和二代測(cè)序技術(shù),開發(fā)Y染色體AZF區(qū)微缺失的全面檢測(cè)方法。結(jié)果 采用的探針捕獲體系,結(jié)合高通量測(cè)序技術(shù),能精確檢測(cè)AZF區(qū)微缺失類型、缺失區(qū)域及缺失引起的DNA拷貝數(shù)變化、AZF區(qū)微重復(fù),發(fā)現(xiàn)現(xiàn)未知缺失類型。結(jié)論 全面檢測(cè)Y染色體上AZF區(qū)域微缺失的方法可為男性不育診斷、輔助生殖提供依據(jù)。

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金項(xiàng)目(2017J01165)
1 通信作者,E-mail:[email protected]
更新日期/Last Update: 2021-10-15