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[1]劉小梅,莊良武,章斌斌.術(shù)前中性粒細胞/淋巴細胞比值對上皮性卵巢癌患者術(shù)后生存率的影響[J].福建醫(yī)藥雜志,2021,43(04):7-11.
　LIU Xiaomei,ZHUANG Liangwu,ZHANG Binbin.Preoperative neutrophil/lymphocyte ratio predicts postoperative survival rate in patients with epithelial ovarian cancer[J].FUJIAN MEDICAL JOURNAL,2021,43(04):7-11.
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術(shù)前中性粒細胞/淋巴細胞比值對上皮性卵巢癌患者術(shù)后生存率的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年04期
頁碼:
7-11
欄目:
臨床研究
出版日期:
2021-08-15

文章信息/Info

Title:
Preoperative neutrophil/lymphocyte ratio predicts postoperative survival rate in patients with epithelial ovarian cancer
文章編號:
1002-2600(2021)04-0007-05
作者:
劉小梅; 莊良武1; 章斌斌1
廈門大學(xué)附屬福州第二醫(yī)院婦科(福州 350007)
Author(s):
LIU Xiaomei; ZHUANG Liangwu; ZHANG Binbin
Department of Gynaecology，F(xiàn)uzhou Second Hospital affiliated to Xiamen University，F(xiàn)uzhou，F(xiàn)ujian 350007，China
關(guān)鍵詞:
中性粒細胞/淋巴細胞比值; 上皮性卵巢癌; 生存率
Keywords:
neutrophil to lymphocyte ratio (NLR);  epithelial ovarian carcinoma (EOC);  survival rate
分類號:
R737.31
文獻標(biāo)志碼:
B
摘要:
目的 探討上皮性卵巢癌（EOC）術(shù)前中性粒細胞與淋巴細胞比值（NLR）與預(yù)后的相關(guān)性。 方法 回顧性分析93例EOC患者的臨床資料，根據(jù)NLR預(yù)測總生存期（OS）的最優(yōu)截點分組，分為高NLR組和低NLR組，比較兩組病理因素、無進展生存期、總生存期的差異，采用單因素及多因素Cox風(fēng)險分析EOC患者潛在的預(yù)后影響因素。 結(jié)果 術(shù)前NLR預(yù)測OS的最優(yōu)截點為3.0，NLR≥3.0組在FIGO分期Ⅲ～Ⅳ期、不滿意卵巢癌細胞減滅術(shù)、伴有腹水及淋巴轉(zhuǎn)移所占比例，均高于NLR＜3.0（P<0.05）。低NLR組中位PFS（30個月）、中位OS（52個月），均顯著高于NLR組（χ2=7.575，P<0.05；χ2=10.035，P<0.05）。Cox風(fēng)險模型示：年齡、腫瘤細胞減滅術(shù)、淋巴轉(zhuǎn)移、NLR≥3.0，均是PFS的獨立危險因素；FIGO分期、腫瘤細胞減滅術(shù)、NLR≥3.0、血清CA125≥35 U/mL，均是OS的獨立危險因素。 結(jié)論 NLR≥3.0預(yù)示ECO患者預(yù)后不良。
Abstract:
Objective To investigate the correlation between peripheral blood neutrophil and lymphocyte ratio (NLR) and prognosis of epithelial ovarian cancer (EOC)．Methods A total of 93 cases of clinicopathological data in EOC patients were retrospectively analyzed. Based on the optimal cut-off point of the NLR predicting OS，the patients were divided into high NLR group and low NLR. Pathological factors,PFS and OS were compared between the two groups. The single factor and multiple factors Cox risk analysis were used for the potential outcomes of patients with EOC influencing factors．Results According to the ROC curve result analysis，the optimal cut-off value of NLR predicting OS in patients with EOC was 3.0. The FIGO Ⅲ~Ⅳ stages，non-satisfactory ovarian cancer cytoreductive surgery，ascites and lymph node metastasis in NLR≥3.0 were all higher than those in NLR<3.0 (P<0.05)．The median PFS (30 months) and median OS (52 months) in the low NLR group were significantly longer than those in the high NLR group (χ2=7.575，P<0.05; χ2=10.035，P<0.05)．The multivariate Cox analysis results showed that age，ovarian cancer cytoreductive surgery，lymph node metastasis and NLR≥3.0 were all independent risk factors of PFS in EOC patients; advanced FIGO stage，ovarian cancer cytoreductive surgery，serum CA125 level and NLR≥3.0 were all independent risk factors of OS in EOC patients．Conclusion NLR≥3.0 predicts poor prognosis in patients with EOC．

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　SHEN Minghong.Analysis of HMGB3 expression and prognostic value in epithelial ovarian cancer based on bioinformatics[J].FUJIAN MEDICAL JOURNAL,2023,45(04):1.

備注/Memo

備注/Memo:
1 福建中醫(yī)藥大學(xué)附屬人民醫(yī)院婦科
更新日期/Last Update: 2021-08-15