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[1]伍林招,張韜,劉巖,等.親水改性聚乳酸基可降解骨支架的制備及性能研究[J].福建醫(yī)藥雜志,2021,43(03):106-108.
　WU Linzhao,ZHANG Tao,LIU Yan,et al.Preparation and properties of hydrophilic modified polylactide based degradable bone scaffolds[J].FUJIAN MEDICAL JOURNAL,2021,43(03):106-108.
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親水改性聚乳酸基可降解骨支架的制備及性能研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數:
2021年03期
頁碼:
106-108
欄目:
基礎研究
出版日期:
2021-06-15

文章信息/Info

Title:
Preparation and properties of hydrophilic modified polylactide based degradable bone scaffolds
文章編號:
1002-2600(2021)03-0106-03
作者:
伍林招; 張韜1; 劉巖; 劉楠楠
廈門大學附屬福州第二醫(yī)院骨科研究所(福州 350007)
Author(s):
WU Linzhao;  ZHANG Tao;  LIU Yan;  LIU Nannan
Department of Orthopedics Institute, the Affiliated Fuzhou Municipal Second Hospital,Xiamen University, Fuzhou,Fujian 350007, China
關鍵詞:
骨組織工程;  骨組織修復;  支架
Keywords:
bone tissue engineering;  bone repair;  scaffold
分類號:
R68
文獻標志碼:
B
摘要:
目的 利用3-氨基-1.2-丙二醇對聚乳酸進行親水改性,制備具有多孔形貌的親水性仿生骨組織工程支架。方法 利用氨解反應對聚乳酸進行親水改性,利用熱致相分離法結合冷凍干燥法制備親水性多孔骨組織工程支架,研究不同凝膠化時間對多孔支架的微觀形貌及親水性能的影響。結果 SEM圖顯示支架呈多孔狀結構,支架的親水性能增強。結論本研究開發(fā)的親水性聚乳酸基多孔海綿狀結構的骨組織工程支架適合于細胞生長,有利于細胞黏附,更有利于骨組織修復,有望應用于臨床。
Abstract:
Objective To prepare a hydrophilic bionic bone tissue engineering scaffold with porous morphology by hydrophilic modification of polylactic acid with 3-amino-1.2-propanediol.Methods The hydrophilic porous bone tissue engineering scaffolds were prepared by thermally induced phase separation and freeze-drying method.The effects of different gelation time on the microstructure and hydrophilicity of the scaffolds were studied.Results SEM showed that the scaffold had a porous structure and its hydrophilicity was enhanced.Conclusion The hydrophilic polylactide based spongy structure scaffold developed in this study is suitable for cell growth, conducive to cell adhesion and more conducive to bone tissue repair and is expected to be used in clinic.

參考文獻/References:

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相似文獻/References:

[1]伍林招 吳學軍.聚己內酯/殼聚糖-磷酸鈣骨水泥支架的制備及其性能研究[J].福建醫(yī)藥雜志,2020,42(01):31.

備注/Memo

備注/Memo:
基金項目:2019年福州市科技計劃項目(2019-SZ-13); 2020年福州市衛(wèi)生健康科技創(chuàng)新平臺建設項目(2020-S-wp3); 福建省級臨床重點專科建設項目
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更新日期/Last Update: 2021-06-15