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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:

43

期數:

2021年03期

頁碼:

26-29

欄目:

臨床研究

出版日期:

2021-06-15

文章信息/Info

Title:

Value of lung biopsy combined with SCC,CEA and NSE in the diagnosis of lung cancer

文章編號:

1002-2600(2021)03-0026-04

作者:

李天林; 余薇; 陳亮; 李遠鵬; 黃馨瑩; 許東平; 劉俊安

華僑大學附屬廈門長庚醫(yī)院呼吸與危重癥醫(yī)學科(廈門 361028)

Author(s):

LI Tianlin;  YU Wei;  CHEN Liang;  LI Yuanpeng;  HUANG Xinying;  XU Dongping;  LIU Junan

Department of Respiratory,Xiamen Changgeng Hospital Affiliated to Huaqiao University,Xiamen, Fujian 361028, China

關鍵詞:

肺部穿刺活檢;  鱗癌抗原;  癌胚抗原;  肺癌;  臨床價值

Keywords:

lung biopsy;  SCC;  CEA;  lung cancer;  clinical value

分類號:

R734.2

文獻標志碼:

B

摘要:

目的 探討肺部穿刺活檢聯合鱗癌抗原(SCC)、癌胚抗原(CEA)、神經元特異度烯醇化酶(NSE)檢測診斷肺癌的價值分析。方法 選取本院2016年1月至2020年4月就診的90例確診肺癌患者為觀察組,選取同時期來院就診的90例肺部良性病變患者及90例健康體檢者分別作為良性組與對照組,比較3組血清SCC、CEA、NSE水平,同時分析觀察組不同病理類型、分期上述指標的差異,分析肺部穿刺活檢、血清SCC、CEA、NSE單獨及聯合檢測在肺癌診斷中的價值。結果 觀察組血清SCC、CEA、NSE水平均高于良性組及對照組(P<0.05); 肺鱗癌者血清SCC水平較肺腺癌及小細胞肺癌明顯升高(P<0.05); 小細胞肺癌者血清NSE水平較肺腺癌及肺鱗癌明顯升高(P<0.05); 肺腺癌者血清CEA水平較肺鱗癌及小細胞肺癌明顯升高(P<0.05); 周圍型肺癌穿刺活檢陽性率為94.64%,并發(fā)癥發(fā)生率為25.56%; 穿刺活檢聯合SCC、CEA、NSE檢測診斷肺癌的敏感度95.56%,特異度100%。結論 肺部穿刺活檢診斷周圍型肺癌陽性率高,并發(fā)癥少,聯合SCC、CEA、NSE檢測能提高診斷肺癌的敏感度與特異度,具有較高臨床價值。

Abstract:

Objective To study the value of lung biopsy combined with SCC,CEA and NSE in the diagnosis of lung cancer.Methods Ninety patients with lung cancer in our hospital from January 2016 to April 2020 were selected as the observation group, and 90 patients with pulmonary benign disease and 90 healthy persons were selected as benign group and control group respectively.The serum levels of SCC, CEA and NSE in the three groups were compared, and the differences of the above indexes in different pathological types and stages of the observation group were analyzed, and the value of lung biopsy and serum three separate and combined detection in the diagnosis of lung cancer was analyzed.Results The serum levels of SCC, CEA and NSE in the observation group were higher than those in the benign group or the control group(P<0.05); the serum SCC level of patients with lung squamous cell carcinoma was significantly higher than that of lung adenocarcinoma and small cell lung cancer(P<0.05); the serum NSE level of small cell lung cancer was significantly higher than that of lung adenocarcinoma and small cell lung cancer(P<0.05); the serum CEA level of lung adenocarcinoma was significantly higher than that of lung squamous cell carcinoma and small cell lung cancer(P<0.05).The positive rate of biopsy was 94.64% and the incidence of complications was 25.56%.The sensitivity and specificity of biopsy combined with SCC, CEA and NSE were 95.56% and 100%, respectively.Conclusion Lung biopsy has high positive rate and less complications in the diagnosis of peripheral lung cancer.Combined detection of SCC, CEA and NSE can improve the sensitivity and specificity of diagnosis of lung cancer, and has high clinical value.

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更新日期/Last Update: 2021-06-15