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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:

43

期數(shù):

2021年03期

頁碼:

19-22

欄目:

臨床研究

出版日期:

2021-06-15

文章信息/Info

Title:

Application effect of insulin pump in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis

文章編號(hào):

1002-2600(2021)03-0019-04

作者:

何金蘭

福建省龍巖人民醫(yī)院內(nèi)分泌科(龍巖 364000)

Author(s):

HE Jinlan

Department of Endocrinology, Longyan People’s Hospital of Fujian, Longyan, Fujian 364000, China

關(guān)鍵詞:

胰島素泵;  傳統(tǒng)皮下注射;  2型糖尿病;  頸動(dòng)脈粥樣硬化

Keywords:

insulin pump;  traditional subcutaneous injection;  type 2 diabetes mellitus;  carotid atherosclerosis

分類號(hào):

R587.2

文獻(xiàn)標(biāo)志碼:

B

摘要:

目的 研究胰島素泵在2型糖尿病(T2DM)伴頸動(dòng)脈粥樣硬化患者中的應(yīng)用效果。方法 選取192例確診為T2DM伴頸動(dòng)脈粥樣硬化患者,按照隨機(jī)數(shù)字表法分為研究組和對(duì)照組各96例。對(duì)照組使用傳統(tǒng)皮下注射給藥方式治療,每日三餐前注射給藥; 研究組采用胰島素泵持續(xù)注射給藥治療。比較兩組患者治療前及治療2個(gè)月后糖代謝指標(biāo)(FBG、P2hBG、GHbA1C)、脂代謝指標(biāo)(HDL-C、LDL-C、TG、TC)、FINS情況。觀察并統(tǒng)計(jì)兩組患者治療過程中低血糖發(fā)生情況。結(jié)果 治療2個(gè)月后,兩組患者FBG、P2hBG、GHbA1C、LDL-C、TG、TC、FINS均較治療前明顯降低(P<0.05),且研究組明顯低于同期對(duì)照組(P<0.05); 兩組患者HDL-C均較治療前明顯升高(P<0.05),且研究組明顯高于同期對(duì)照組(P<0.05); 治療過程中研究組患者低血糖發(fā)生次數(shù)明顯小于對(duì)照組(P<0.05)。結(jié)論 胰島素泵治療T2DM伴頸動(dòng)脈粥樣硬化患者可明顯且安全降低其血糖血脂水平,對(duì)比傳統(tǒng)皮下注射治療效果更顯著,對(duì)改善其預(yù)后具有積極作用。

Abstract:

Objective To study the application effect of insulin pump in patients with type 2 diabetes mellitus(T2DM)complicated with carotid atherosclerosis.Methods One hundred and ninety-two patients diagnosed with T2DM complicated with carotid atherosclerosis were selected and divided into study group and control group with 96 cases in each group according to the random number table method.Control group was treated with traditional subcutaneous injection, and was injected before three meals a day.Study group was treated with continuous injection of insulin pump.The glucose metabolism indicators(FBG, P2hBG, GHbA1C), lipid metabolism indicators(HDL-C, LDL-C, TG, TC)and FINS were compared between the two groups of patients before treatment and after 2 months of treatment.The occurrence of hypoglycemia was observed and counted in the two groups of patients during treatment.Results After 2 months of treatment, the levels of FBG, P2hBG, GHbA1C, LDL-C, TG, TC and FINS of the two groups were significantly decreased compared to previous treatment(P<0.05), and the levels of study group were significantly lower than those of control group during the same period(P<0.05).The HDL-C level of the two groups of patients was obviously increased compared with that before treatment(P<0.05), and the level of study group was significantly higher than that of control group during the same period(P<0.05).The frequency of hypoglycemia occurrence in study group was significantly less than that in control group during treatment(P<0.05).Conclusion Insulin pump for the treatment of T2DM patients complicated with carotid atherosclerosis can significantly and safely reduce the levels of blood glucose and blood lipids.Compared to traditional subcutaneous injection, it has a more significant effect and has a positive effect on improving the prognosis.

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更新日期/Last Update: 2021-06-15