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[1]林榕波,趙 珅,蘇麗玉.紫杉醇和奧沙利鉑聯(lián)合5-氟尿嘧啶和亞葉酸二線治療晚期膽管癌38例療效觀察[J].福建醫(yī)藥雜志,2021,43(02):48-50.
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紫杉醇和奧沙利鉑聯(lián)合5-氟尿嘧啶和亞葉酸二線治療晚期膽管癌38例療效觀察()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年02期
頁碼:
48-50
欄目:
臨床研究
出版日期:
2021-04-15

文章信息/Info

文章編號(hào):
1002-2600(2021)02-0048-03
作者:
林榕波趙 珅蘇麗玉
福建醫(yī)科大學(xué)附屬腫瘤醫(yī)院腹部內(nèi)科(福州 350014)
關(guān)鍵詞:
膽管癌 二線化療 紫杉醇 奧沙利鉑 5-氟尿嘧啶
分類號(hào):
R735.8
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討紫杉醇和奧沙利鉑聯(lián)合5-氟尿嘧啶(5-FU)和亞葉酸二線治療晚期膽管癌患者的療效和安全性。方法 選取既往接受過一線化療失敗的晚期膽管癌患者38例,予紫杉醇135 mg/m2、奧沙利鉑85 mg/m2、亞葉酸400 mg/m2,第1天; 5-FU 2 400 mg/m2,持續(xù)靜脈輸注46 h,每14天重復(fù)。結(jié)果 本組晚期膽管癌患者中位疾病無進(jìn)展時(shí)間和總生存時(shí)間分別為4.0和7.2個(gè)月。9例(23.6%)出現(xiàn)部分緩解,14例(36.8%)處于疾病穩(wěn)定,3~4級(jí)的毒性反應(yīng)較少且可控。結(jié)論 紫杉醇和奧沙利鉑聯(lián)合5-FU和亞葉酸二線治療晚期膽管癌患者安全、有效。

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更新日期/Last Update: 2021-04-15