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[1]孫伏清,林永芳,周 密,等.他汀強(qiáng)化預(yù)處理對(duì)PCI介導(dǎo)CEMPAS的防治效果觀察[J].福建醫(yī)藥雜志,2021,43(02):27-30.
　SUN Fuqing,LIN Yongfang,ZHOU Mi,et al.Statin pretreatment and intensive therapy for distal coronary embolization and abnormal myocardial perfusion related to percutaneous coronary interventions(CEMPAS)[J].FUJIAN MEDICAL JOURNAL,2021,43(02):27-30.
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他汀強(qiáng)化預(yù)處理對(duì)PCI介導(dǎo)CEMPAS的防治效果觀察()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年02期
頁碼:
27-30
欄目:
臨床研究
出版日期:
2021-04-15

文章信息/Info

Title:
Statin pretreatment and intensive therapy for distal coronary embolization and abnormal myocardial perfusion related to percutaneous coronary interventions(CEMPAS)
文章編號(hào):
1002-2600(2021)02-0027-04
作者:
孫伏清; 林永芳; 周 密; 郭 城; 黃 奇; 林凱金; 陳 平
福建醫(yī)科大學(xué)附屬福清市醫(yī)院 福建省福清市醫(yī)院心血管內(nèi)科(福清 350300)
Author(s):
SUN Fuqing;  LIN Yongfang;  ZHOU Mi;  GUO Cheng;  HUANG Qi;  LIN Kaijin;  CHEN Ping
Department of Cardiovascular,Fuqing Municipal Hospital, Fuqing Municipal Hospital Affiliated to Fujian Medical University,Fuqing,Fujian 350300,China
關(guān)鍵詞:
他汀;  急性冠脈綜合征;  經(jīng)皮冠脈介入手術(shù)
Keywords:
statin;  acute coronary syndrome;  percutaneous coronary intervention
分類號(hào):
R543.3; R540.46
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討他汀類藥物強(qiáng)化預(yù)處理對(duì)經(jīng)皮冠狀動(dòng)脈介入治療(PCI)介導(dǎo)的相關(guān)性遠(yuǎn)端血管栓塞及心肌灌注障礙(CEMPAS)的防治效果。方法 選擇212例具備PCI術(shù)指征的急性冠脈綜合征(ACS)患者,男156例,女66例; 年齡(65±11)歲。隨機(jī)分為兩組:110例術(shù)前7 d服用阿托伐他汀40 mg/d強(qiáng)化治療, 其余102例服用阿托伐他汀20 mg/d常規(guī)劑量治療。分別測(cè)量PCI術(shù)前及PCI術(shù)后心肌梗死溶栓治療(TIMI)血流水平及術(shù)后6 h肌鈣蛋白I(TnI)、肌酸激酶同工酶(CK-MB)、高敏C反應(yīng)蛋白(hs-CRP),并評(píng)估兩組患者臨床隨訪3個(gè)月的主要心血管事件。結(jié)果 兩組患者的基線水平及血管造影的特征具有可比性。PCI術(shù)前兩組患者的TnI 、CK-MB 和 hs-CRP 水平無差異; PCI術(shù)后TnI、CK-MB和hs-CRP水平均增加。他汀強(qiáng)化治療組患者與常規(guī)劑量他汀治療組比較,PCI術(shù)后即刻3級(jí)血流發(fā)生率[(99.5±5.2)% vs(96.7±5.0)%,P<0.05]較高,術(shù)后6 h TnI、CK-MB、hs-CRP水平[(0.36±0.12)vs(1.33±0.47)ng/mL, P<0.01;(14.2±5.78)vs(47.3±16.4)IU/L, P<0.05;(6.42±3.56)vs(8.23±3.67)mg/L, P<0.05]及隨訪3個(gè)月的主要心血管事件發(fā)生率(0.9% vs 2.9%, P<0.05; 0.9% vs 3.9%, P<0.05; 0.9% vs 2.9%, P<0.05)均明顯降低。結(jié)論 該研究表明ACS患者實(shí)施阿托伐他汀強(qiáng)化預(yù)處理具有改善PCI介導(dǎo)的CEMPAS的防治效果。
Abstract:
Objective This study sought to investigate potential protective effects of atorvastatin in patients with CEMPAS undergoing percutaneous coronary intervention(PCI).Methods A total of 212 ACS patients [156 males and 66 females, aged(65±11)years] with PCI indications were randomly divided into two groups: 110 cases were taken seven days before PCI with atorvastatin 40 mg/day intensive treatment,and the remaining 102 patients were treated with regular doses of atorvastatin 20 mg/day. The thrombolysis in myocardial infarction(TIMI)blood flow levels before and after PCI, and TnI, CK-MB, and hs-CRP six hours after operation weremeasured, and the major cardiovascular events within three months of clinical follow-up in both groups were assessed.Results Baseline clinical and angiographic characteristics of the two groups of patients were comparable.There were no differences in TnI, CK-MB and hs-CRP levels between the two groups of patients before PCI.TnI, CK-MB and hs-CRP levels increased after PCI.Patients in the statin intensive treatment group had slow blood flow or no regurgitation immediately after PCI.The levels of TnI, CK-MB, and hs-CRP at six hours after surgery were followed.Compared with maintaining regular doses of statin group, the major cardiovascular events during the 3-month follow-up period were significantly reduced.Conclusion The study shows that intensive atorvastatin pretreatment in patients with ACS can improve the prevention and treatment of PCI-mediated CEMPAS.

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更新日期/Last Update: 2021-04-15