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[1]林 萍,鄭淑霞,官瑞婷,等.伴異常染色體核型的初診急性髓系白血病臨床及實(shí)驗(yàn)室特征分析[J].福建醫(yī)藥雜志,2021,43(02):21-24.
　LIN Ping,ZHENG Shuxia,GUAN Ruiting,et al.Clinical and laboratory characteristics and prognostic factors of initial diagnosed acute myeloid leukemia with abnormal karyotype[J].FUJIAN MEDICAL JOURNAL,2021,43(02):21-24.
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伴異常染色體核型的初診急性髓系白血病臨床及實(shí)驗(yàn)室特征分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年02期
頁(yè)碼:
21-24
欄目:
臨床研究
出版日期:
2021-04-15

文章信息/Info

Title:
Clinical and laboratory characteristics and prognostic factors of initial diagnosed acute myeloid leukemia with abnormal karyotype
文章編號(hào):
1002-2600(2021)02-0021-04
作者:
林 萍; 鄭淑霞; 官瑞婷; 張雅蘭; 杜秀環(huán); 葉小翠; 謝若騰1
福建醫(yī)科大學(xué)附屬第二醫(yī)院檢驗(yàn)科(泉州 362000)
Author(s):
LIN Ping;  ZHENG Shuxia;  GUAN Ruiting;  ZHANG Yalan;  DU Xiuhuan;  YE Xiaocui;  XIE Ruoteng
Department of Medical Laboratory, the Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian 362000,China
關(guān)鍵詞:
染色體;  染色體核型異常;  急性髓系白血病; AML;  臨床特征;  病態(tài)造血
Keywords:
chromosome;  chromosome karyotype abnormality;  acute myeloid leukemia; AML;  clinical features;  morbid hematopoiesis
分類號(hào):
R733.71
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討伴異常染色體核型的初診急性髓系白血病(acute myeloid leukemia,AML)患者的臨床、實(shí)驗(yàn)室特征。方法 收集我院收治的伴異常染色體核型的初診AML患者資料,分析其臨床及實(shí)驗(yàn)室資料。結(jié)果 除M2b外14例患者骨髓合并病態(tài)造血,FAB分型中M2a13例、M51例,染色體核型中復(fù)雜核型10例、單體核型2例、染色體易位2例。71例異常染色體核型表現(xiàn)為染色體易位42例(其中M2b6例,M321例,M4EO4例)、單體核型14例、復(fù)雜核型15例。結(jié)論 伴異常染色體核型的初診AML以染色體易位為主,但除M2b、M3、M4EO外,3種染色體核型異常(染色體易位、單體核型、復(fù)雜核型)無(wú)明顯差異。合并病態(tài)造血的AML多見(jiàn)于復(fù)雜核型且以M2a為主。
Abstract:
Objective To investigate the clinical and laboratory features and prognosis of initial diagnosed acute myeloid leukemia(AML)patients with abnormal karyotype.Methods Clinical laboratory data and prognostic factors of initial diagnosed AML patients with abnormal karyotype admitted to our hospital were retrospectively analyzed.Results In addition to M2b, 14 patients had morbid hematopoiesis in bone marrow,according to FAB classification, 23 cases were M2a and 1 case was M5.Among the 71 cases of abnormal karyotypes, there were mainly 42 cases of chromosomal translocations(there were 6 cases of M2b, 21 cases of M3 and 4 cases of M4EO), 14 cases of monomer karyotypes and 15 cases of complex karyotypes. Conclusion The newly diagnosed AML patients with abnormal karyotype are mainly chromosomal translocation,except M2b,M3,and M4EO, there is no significant difference among the three karyotypes(chromosomal translocation,monomer karyotype,and complex karyotype).AML with morbid hematopoiesis is more common in patients with complex karyotype and M2a is the main type.

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備注/Memo

備注/Memo:
1 通信作者,Email: [email protected]
更新日期/Last Update: 2021-04-15