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[1]潘云虎,季志宇,劉國生,等.蘇黃止咳膠囊對減輕肺炎支原體肺部感染大鼠炎癥反應(yīng)的作用及機制探討[J].福建醫(yī)藥雜志,2021,43(01):124-126.
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蘇黃止咳膠囊對減輕肺炎支原體肺部感染大鼠炎癥反應(yīng)的作用及機制探討()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年01期
頁碼:
124-126
欄目:
基礎(chǔ)研究
出版日期:
2021-02-10

文章信息/Info

文章編號:
1002-2600(2021)01-0124-03
作者:
潘云虎季志宇劉國生李發(fā)根陳藝壇
聯(lián)勤保障部隊第九O七醫(yī)院(南平 353000)
關(guān)鍵詞:
肺炎支原體 蘇黃止咳膠囊 TGF-β KL-6 SP-D
分類號:
R563.1
文獻標志碼:
B
摘要:
目的 探討蘇黃止咳膠囊在肺炎支原體肺部感染大鼠中的作用及相關(guān)機制。方法 將雄性SD大鼠隨機分為5組,分別為正常對照組、肺炎支原體肺部感染組和肺炎支原體肺部感染蘇黃止咳膠囊不同劑量組(低劑量組,3.5 g/kg; 中等劑量組7 g/kg; 高劑量組14 g/kg)。肺炎支原體肺部感染大鼠模型通過在24周內(nèi)反復(fù)9次經(jīng)超聲霧化吸入肺炎支原體構(gòu)建。各組給予留取大鼠肺泡灌洗液進行細胞計數(shù)分析及TGF-β、KL-6和SP-D濃度檢測。結(jié)果 肺炎支原體肺部感染各組大鼠肺泡灌洗液中巨噬細胞計數(shù)、中性粒細胞計數(shù)及TGF-β、KL-6和SP-D 濃度明顯高于正常對照組(P<0.05),在蘇黃止咳膠囊中等劑量及高劑量治療組,巨噬細胞計數(shù)及中性粒細胞計數(shù)及3種細胞因子水平明顯低于未治療組(P<0.05)。結(jié)論 蘇黃止咳膠囊可以通過抑制TGF-β、KL-6和SP-D水平從而減輕肺炎支原體所致大鼠肺部炎癥反應(yīng),可能在肺炎支原體感染中有一定的臨床應(yīng)用價值。

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備注/Memo

備注/Memo:
基金項目:2014年度軍區(qū)醫(yī)學(xué)科技創(chuàng)新課題項目(14ZD32)
更新日期/Last Update: 2021-02-10