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[1]楊則堂,關(guān)海山,許紅波,等.臍帶血堿性磷酸酶在新生兒黃疸診斷中的應(yīng)用價值[J].福建醫(yī)藥雜志,2021,43(01):92-95.
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臍帶血堿性磷酸酶在新生兒黃疸診斷中的應(yīng)用價值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年01期
頁碼:
92-95
欄目:
臨床研究
出版日期:
2021-02-10

文章信息/Info

文章編號:
1002-2600(2021)01-0092-04
作者:
楊則堂關(guān)海山許紅波李紅王源
福建省廈門長庚醫(yī)院兒科(廈門 460000)
關(guān)鍵詞:
臍帶血 堿性磷酸酶 新生兒 高膽紅素血癥
分類號:
R722.17
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討臍帶血堿性磷酸酶在預(yù)測新生兒高膽紅素血癥發(fā)生中的有效性及診斷價值。方法 采用我院2018年6月至2019年6月出生的216例新生兒作為研究對象,詳細(xì)紀(jì)錄了新生兒及其母親的一般情況; 出生后即時測定臍靜脈血堿性磷酸酶水平,并監(jiān)測黃疸新生兒血清膽紅素,根據(jù)血清膽紅素水平進(jìn)行治療; 對各組新生兒堿性磷酸酶水平進(jìn)行比較,通過受試者工作特征(ROC)曲線評價臍帶血堿性磷酸酶在診斷新生兒高膽紅素血癥中的價值。結(jié)果 非黃疸組平均堿性磷酸酶(280.21±42.50)IU /L; 臨床黃疸組堿性磷酸酶(292.25±40.25)IU/L; 血清膽紅素≥12.1 mg/dL的黃疸組堿性磷酸酶為(312.60±48.64)IU/L(P<0.05)。以小時膽紅素曲線進(jìn)行治療,黃疸組臍帶血中堿性磷酸酶為(315.80±43.82)IU/L(P<0.05)。臍帶血中堿性磷酸酶以300 IU/L作為臨界值預(yù)測需要治療的新生兒高膽紅素血癥的敏感度為83%,特異度為85%。結(jié)論 臍帶血堿性磷酸酶水平可作為預(yù)測足月兒即將發(fā)生嚴(yán)重的高膽紅素血癥的指標(biāo)。

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更新日期/Last Update: 2021-02-10