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[1]林建光,許天文.白蛋白紫杉醇與多西他賽一線治療老年晚期肺鱗癌的療效比較[J].福建醫(yī)藥雜志,2021,43(01):51-54.
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白蛋白紫杉醇與多西他賽一線治療老年晚期肺鱗癌的療效比較()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年01期
頁碼:
51-54
欄目:
臨床研究
出版日期:
2021-02-10

文章信息/Info

文章編號:
1002-2600(2021)01-0051-03
作者:
林建光許天文1
福建醫(yī)科大學(xué)附屬第二醫(yī)院腫瘤內(nèi)科(泉州 362000)
關(guān)鍵詞:
老年 晚期肺癌 鱗癌 白蛋白紫杉醇 多西他賽
分類號:
R734.2
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 觀察比較白蛋白紫杉醇與多西他賽單藥一線治療老年晚期肺鱗癌患者的療效及不良反應(yīng)。方法 回顧性分析我院收治的120例老年晚期肺鱗癌患者的臨床資料,其中白蛋白紫杉醇組60例、多西他賽組60例,比較兩者的療效及不良反應(yīng)。結(jié)果 白蛋白紫杉醇組與多西他賽組的無進(jìn)展生存期(PFS)、總生存期(OS)、緩解率(RR)、疾病控制率(DCR)分別為5.2個月和3.3個月,12.4個月和9.0個月,35.0%和21.7%,70.0%和55.0%。白蛋白紫杉醇組的PFS、OS優(yōu)于多西他賽組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05),而兩組RR、DCR差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。白蛋白紫杉醇組失眠、血糖升高不良反應(yīng)發(fā)生率低于多西他賽組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 單藥白蛋白紫杉醇一線治療老年晚期肺鱗癌的療效優(yōu)于單藥多西他賽,且不良反應(yīng)發(fā)生率低,值得推薦。

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更新日期/Last Update: 2021-02-10