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[1]蘇月卿,劉春鳳,林美娜,等.淋巴結(jié)切除個數(shù)對IB1~ⅡA2期宮頸癌患者預(yù)后的影響分析[J].福建醫(yī)藥雜志,2021,43(01):48-51.
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淋巴結(jié)切除個數(shù)對IB1~ⅡA2期宮頸癌患者預(yù)后的影響分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年01期
頁碼:
48-51
欄目:
臨床研究
出版日期:
2021-02-10

文章信息/Info

文章編號:
1002-2600(2021)01-0048-04
作者:
蘇月卿劉春鳳林美娜祖水玲1
福建醫(yī)科大學(xué)附屬第二醫(yī)院婦產(chǎn)科(泉州 362000)1 福建中醫(yī)藥大學(xué)附屬第三人民醫(yī)院,通信作者,Email:[email protected]
關(guān)鍵詞:
子宮頸腫瘤 淋巴結(jié) 預(yù)后 切除
分類號:
R737.33
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討淋巴結(jié)切除個數(shù)對IB1~ⅡA2期宮頸癌患者預(yù)后的影響。方法 回顧性分析行根治性手術(shù)治療的IB1~ⅡA2期宮頸癌473例,根據(jù)淋巴結(jié)切除個數(shù)的四分位數(shù)進(jìn)行分組,分為A組(1~11個)、B組(12~16個)、C組(17~20個)、D組(≥21個)。比較4組間年齡、FIGO分期、腫瘤直徑、組織學(xué)類型、組織學(xué)分級、宮頸肌層浸潤、淋巴脈管間隙浸潤(LVSI)、宮旁轉(zhuǎn)移、陰道切緣浸潤、淋巴結(jié)轉(zhuǎn)移的差異。生存分析采用Kaplan-Meier法,比較4組間無瘤生存率(DFS)和總體生存率(OS)的差異。預(yù)后的獨立危險因素采用多因素Cox比例風(fēng)險回歸模型。結(jié)果 4組組間在年齡、FIGO分期、腫瘤直徑、組織學(xué)類型、組織學(xué)分級、宮頸肌層浸潤、LVSI、宮旁轉(zhuǎn)移、陰道切緣浸潤和淋巴結(jié)轉(zhuǎn)移方面差異均無統(tǒng)計學(xué)意義(P>0.05)。采用Kaplan-Meier法計算出的A組、B組、C組、D組的5年DFS分別為79.0%、89.6%、92.3%、90.9%,5年OS分別為75.8%、92.1%、96.9%、93.9%,兩兩比較后,A組的5年DFS和OS均低于其他3組,而其他3組間差異均無統(tǒng)計學(xué)意義(均P>0.05)。Cox多因素回歸分析顯示相比于A組,B組至D組是患者更好的DFS和OS的獨立保護(hù)因素。結(jié)論 IB1~ⅡA2期宮頸癌患者淋巴結(jié)切除個數(shù)與預(yù)后有關(guān),切除數(shù)>11個患者預(yù)后更好。

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更新日期/Last Update: 2021-02-10