80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]林志堅(jiān) 王增春 趙秋燕 黃飛彬.羥考酮和芬太尼用于婦科腹腔鏡手術(shù)術(shù)后鎮(zhèn)痛的效果比較[J].福建醫(yī)藥雜志,2020,42(06):25-29.
　LIN Zhijian,WANG Zengchun,ZHAO Qiuyan,et al.Comparison of effects of oxycodone and fentanyl for postoperative analgesia of gynecological laparoscopic surgery[J].FUJIAN MEDICAL JOURNAL,2020,42(06):25-29.
點(diǎn)擊復(fù)制

羥考酮和芬太尼用于婦科腹腔鏡手術(shù)術(shù)后鎮(zhèn)痛的效果比較()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年06期
頁(yè)碼:
25-29
欄目:
臨床研究
出版日期:
2020-12-15

文章信息/Info

Title:
Comparison of effects of oxycodone and fentanyl for postoperative analgesia of gynecological laparoscopic surgery
文章編號(hào):
1002-2600(2020)06-0025-05
作者:
林志堅(jiān) 王增春1 趙秋燕 黃飛彬
福建醫(yī)科大學(xué)附屬漳州市醫(yī)院麻醉科(漳州 363000)
Author(s):
LIN Zhijian; WANG Zengchun; ZHAO Qiuyan; HUANG Feibin.
Department of Anesthesiology, the Affiliated Zhangzhou Municipal Hospital,Fujian Medical University, Zhangzhou, Fujian 363000, China
關(guān)鍵詞:
羥考酮;  芬太尼;  婦科腹腔鏡;  術(shù)后鎮(zhèn)痛
Keywords:
oxycodone;  fentanyl;  gynecological laparoscopic;  postoperative analgesia
分類(lèi)號(hào):
R614
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 觀察羥考酮對(duì)婦科腹腔鏡手術(shù)術(shù)后鎮(zhèn)痛的影響。方法 選取擬擇期行腹腔鏡手術(shù)的婦科患者80例,年齡18～53歲,ASAⅠ～Ⅱ級(jí)。將患者隨機(jī)分為兩組:羥考酮組(O組)和芬太尼組(F組),兩組分別于關(guān)腹前5 min給予靜脈注射羥考酮10 mg和芬太尼0.1 mg。記錄拔管后15、30及60 min時(shí)的數(shù)字評(píng)價(jià)量表(NRS)評(píng)分、Ramsay鎮(zhèn)靜評(píng)分并觀察是否呼吸抑制發(fā)生; 記錄術(shù)后2、4、8、12和24 h靜息和活動(dòng)時(shí)的NRS評(píng)分; 記錄術(shù)后首次出現(xiàn)NRS≥4分的時(shí)間、術(shù)后要求追加鎮(zhèn)痛的例數(shù)、術(shù)后惡心嘔吐(PONV)的例數(shù); 評(píng)估術(shù)后24 h患者滿(mǎn)意度并進(jìn)行舒適度(BCS)評(píng)分。結(jié)果 兩組拔管后15、30及60 min時(shí)的NRS評(píng)分和Ramsay鎮(zhèn)靜評(píng)分差異無(wú)統(tǒng)計(jì)學(xué)意義,也均未發(fā)生呼吸抑制; O組術(shù)后2、4、8 h靜息和運(yùn)動(dòng)的NRS評(píng)分顯著低于F組(P<0.05),而兩組術(shù)后12 h與24 h時(shí)靜息和活動(dòng)的NRS評(píng)分差異無(wú)統(tǒng)計(jì)學(xué)意義; O組術(shù)后首次出現(xiàn)NRS≥4分的時(shí)間顯著大于F組(P<0.05),而且術(shù)后要求給予追加鎮(zhèn)痛的例數(shù)也少于F組(P<0.05); O組PONV發(fā)生率低于F組(P<0.05); O組術(shù)后24 h的患者滿(mǎn)意度明顯高于F組(P<0.05); 兩組術(shù)后24 h BCS舒適度評(píng)分差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論 羥考酮能有效緩解婦科腔鏡術(shù)后早期疼痛,時(shí)效性明顯; 且較于芬太尼,羥考酮作為術(shù)后鎮(zhèn)痛中的阿片類(lèi)藥物,其相關(guān)不良反應(yīng)的發(fā)生率也明顯降低。
Abstract:
Objective To explore the clinical effect of oxycodone for postoperative analgesia of gynecological laparoscopic surgery.Methods Eighty patients undergoing elective gynecologic laparoscopic surgery,aged 18 to 53 years,with ASA physical statusⅠorⅡ, were randomly divided into two groups(n=40): oxycodone group(group O)and fentanyl group(group F).Five minutes before closure, oxycodone 10 mg was injected intravenously in group O and fentanyl 0.1 mg in group F.NRS(numerical rating scale)score, Ramsay sedation score and respiratory depression score 15, 30 and 60 min after extubation were recorded.Then the NRS score 2,4,8,12 and 24 hours after operation during rest or movement were recorded.The time for the NRS score more than or equal to four, the number of patients asking for additional analgesia, and the adverse reactions such as PONV were recorded.The satisfaction degree of analgesia and BCS scores in 24 hours were also evaluated.Results There was no difference in the NRS score and Ramsay sedation score at 15,30, 60 min after extubation(P>0.05).No respiratory depression occured in either group.The NRS score during rest or movement in group O at 2, 4 and 8 hours after surgery were significantly lower than those in the group F(P<0.05),but there was no statistically significant difference in NRS pain scores at 12 hours to 24 hours after extubation.Comparison with group F, the first time for the NRS more than or equal to four was much longer(P<0.05), and the number of cases asking for additional analgesia was much less in group O(P<0.05).The incidence of postoperative nausea and vomiting in group O was lower(P<0.05).Patients of group O got a higher degree of satisfaction(P<0.05).The BCS scores of 24 hours after operation had no statistically significant difference in two groups(P>0.05).Conclusion Oxycodone has exactly analgesic effect for laparoscopic gynecologic surgery,which can effectively alleviate the early postoperative pain in minimally invasive surgery.The analgesic limitation has obvious pertinence.Compared with fentanyl,oxycodone has a significantly lower rate of adverse reactions.

參考文獻(xiàn)/References:

[1] 徐建國(guó).鹽酸羥考酮的藥理學(xué)和臨床應(yīng)用[J].臨床麻醉學(xué)雜志,2014, 30(5): 511-513.
[2] Engoren M, Luther G, Fnn-Bunderer N.A comparision of fentany, sufentanil and remifentanil for fast-track cardiac anthesia [J].Anesth Analg,2001,93(4):859-864.
[3] De Schepper H U, Cremonini F, Park M I,et al.Opioids and the gut: pharmacology and current clinical experience[J].Neurogastroenterol Motil,2004,16: 383-394.
[4] Wang J,Ma H,Zhou H,et al.Effect of preoperative intravenous oxycodone administration on sufentanil consumption after retroperitoneal laparoscopic nephrectomy[J].AnaesthesiolIntensive Ther,2016,48(5):300-304.
[5] Staahl C, Christrup L L, Andersen S D,et al.A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model[J].Pain,2006,123(1/2):28-36.
[6] Parky H,Lees H,Leeo H,et al.Optimal dose of intra-venous oxycodone for attenuating hemodynamic changes after endotracheal intubation inhealthy patients: a randomized controlled trial[J].Medicine(Baltimore),2017,96(11): e6234.
[7] Charpiat B,Tod M,Darnis B,et al.Respiratory depression related to multiple drug-druginteractions precipitatedbyafluconazoleloadingdoseinapatienttreated with oxycodone[J].Eur J Clin Pharmacol,2017,73(6): 787-788.
[8] Staahl C, Dimcevski G, Andersen S D,et al.Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study[J].Scand J Gastroenterol, 2007,42(3):383-390.
[9] Gan T J, Diemunsch P, Habib A S,et al.Consensus guidelines for the management of postoperative nausea and vomiting[J].Anesth Analg, 2014, 118(1): 85-113.
[10] 劉欣鑫.婦科腔鏡手術(shù)后惡心嘔吐危險(xiǎn)因素分析[J].中國(guó)現(xiàn)代藥物應(yīng)用,2014, 8(14):90-91.
[11] 許幸,吳新民,薛張綱,等.鹽酸羥考酮注射液用于全麻患者術(shù)后鎮(zhèn)痛的有效性和安全性:前瞻性、隨機(jī)、盲法、多中心、陽(yáng)性對(duì)照臨床研究[J].中華麻醉學(xué)雜志, 2013, 33(3): 269-274.

備注/Memo

備注/Memo:
通信作者,福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院心臟外科(福州350001),電子信箱:[email protected]
更新日期/Last Update: 1900-01-01