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[1]林 勇 林 春 孫 芳 周 銳 楊文彥 周麗娜葉雅妹 潘 晨.乙型肝炎慢加急性肝衰竭患者血清miR-122水平與預(yù)后的相關(guān)性[J].福建醫(yī)藥雜志,2020,42(06):22-25.
　LIN Yong,LIN Chun,SUN Fang,et al.Correlation between serum miR-122 level and prognosis of patients with acute-on-chronic hepatitis B liver failure[J].FUJIAN MEDICAL JOURNAL,2020,42(06):22-25.
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乙型肝炎慢加急性肝衰竭患者血清miR-122水平與預(yù)后的相關(guān)性()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年06期
頁碼:
22-25
欄目:
臨床研究
出版日期:
2020-12-15

文章信息/Info

Title:
Correlation between serum miR-122 level and prognosis of patients with acute-on-chronic hepatitis B liver failure
文章編號(hào):
1002-2600(2020)06-0022-04
作者:
林 勇 林 春 孫 芳 周 銳 楊文彥 周麗娜葉雅妹 潘 晨
福建醫(yī)科大學(xué)孟超肝膽醫(yī)院肝病內(nèi)科(福州 350025)
Author(s):
LIN Yong;  LIN Chun;  SUN Fang; ZHOU Rui;  YANG Wenyan;  ZHOU Lina; YE Yamei;  PAN Chen.
Department of Hepatology Internal Medicine, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025,China
關(guān)鍵詞:
血清miR-122;  乙型肝炎慢加急性肝衰竭;  預(yù)后
Keywords:
serum miRNA-122;  acute-on-chronic hepatitis B liver failure;  prognosis
分類號(hào):
R575.3
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討乙型肝炎慢加急性肝衰竭患者血清miR-122與疾病預(yù)后的相關(guān)性。方法 入組乙型肝炎慢加急性肝衰竭患者52例,收集患者臨床資料、血液生化、乙肝病毒學(xué)指標(biāo)、凝血功能指標(biāo)、血清miR-122水平,計(jì)算終末期肝病模型(MELD)評(píng)分,記錄隨訪3個(gè)月后患者的生存狀態(tài)。采用Spearman相關(guān)分析血清miR-122水平與乙型肝炎慢加急性肝衰竭患者預(yù)后的關(guān)系,并采用非條件logistic回歸進(jìn)行多因素分析。結(jié)果 血清miR-122水平與乙型肝炎慢加急性肝衰竭的預(yù)后呈負(fù)相關(guān)(r=-0.384,P=0.005)。乙型肝炎慢加急性肝衰竭患者血清miR-122表達(dá)與凝血酶原活動(dòng)度(PTA)(P=0.053)、Cr(P=0.050)、預(yù)后(P=0.030)、MELD(P=0.080)具有相關(guān)性。結(jié)論 在乙型肝炎慢加急性肝衰竭患者中,血清miR-122水平與疾病預(yù)后呈負(fù)相關(guān),高水平的血清miR-122可能預(yù)示預(yù)后較好,血清miR-122可能是乙型肝炎慢加急性肝衰竭患者判斷預(yù)后一個(gè)潛在指標(biāo)。
Abstract:
Objective To explore the correlation between serum miR-122 and prognosis of patients with acute-on-chronic hepatitis B liver failure.Methods A total of 52 patients with acute-on-chronic hepatitis B liver failure were enrolled.The clinical data, blood biochemistry, hepatitis B virological index coagulation function index and serum miR-122 level were collected.Followed up and recorded survival status after 3 months,serum miR-122 levels and survival status were analyzed by using Spearman correlation,and nonconditional logistic regression was used for multivariate analysis.Results The results showed that serum miR-122 levels were negatively correlated with the prognosis in patients with acute-on-chronic hepatitis B liver failure(r=-0.384,P=0.005).The expression of serum miR-122 was correlated with PTA(P=0.053), Cr(P=0.050), prognosis(P=0.030)and MELD(P=0.080).Conclusion In patients with acute-on-chronic hepatitis B liver failure, serum miR-122 level is inversely correlated with disease outcome, and high level of serum miR-122 may predict a good prognosis.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福州市科技計(jì)劃項(xiàng)目社會(huì)發(fā)展項(xiàng)目(2018-S-103-4)
更新日期/Last Update: 1900-01-01