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[1]吳火友 向 高 魏金鳳 吳祖蛟 穆建成 余桂華.乙酰肝素酶與血管內(nèi)皮生長(zhǎng)因子在結(jié)直腸腫瘤組織中的表達(dá)及臨床意義[J].福建醫(yī)藥雜志,2020,42(06):17-22.
　WU Huoyou,XIANG Gao,WEI Jinfeng,et al.Expression and significance of HPSE and VEGF in colorectal neoplasms[J].FUJIAN MEDICAL JOURNAL,2020,42(06):17-22.
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乙酰肝素酶與血管內(nèi)皮生長(zhǎng)因子在結(jié)直腸腫瘤組織中的表達(dá)及臨床意義()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年06期
頁碼:
17-22
欄目:
臨床研究
出版日期:
2020-12-15

文章信息/Info

Title:
Expression and significance of HPSE and VEGF in colorectal neoplasms
文章編號(hào):
1002-2600(2020)06-0017-06
作者:
吳火友 向 高1 魏金鳳 吳祖蛟 穆建成 余桂華
福建醫(yī)科大學(xué)附屬南平第一醫(yī)院普外科(南平 353000)
Author(s):
WU Huoyou; XIANG Gao;  WEI Jinfeng;  WU Zujiao; MU Jiancheng; YU Guihua.
Department of General Surgery, the Affiliated Nanping Municipal First Hospital, Fujian Medical University,Nanping,Fujian 353000,China
關(guān)鍵詞:
乙酰肝素酶;  血管內(nèi)皮生長(zhǎng)因子;  結(jié)直腸腫瘤;  免疫組化;  逆轉(zhuǎn)錄聚合酶鏈反應(yīng)
Keywords:
heparanase;  vascular endothelial growth factor;  colorectal neoplasms;  immunohistochemistry;  reverse transcriptate polymerase chain reatction
分類號(hào):
R735.3
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 研究乙酰肝素酶(heparanase,HPSE)及血管內(nèi)皮生長(zhǎng)因子(vascular endothelial growth factor,VEGF)在結(jié)直腸腫瘤患者組織中表達(dá)情況及臨床意義。方法 選取經(jīng)手術(shù)及病理證實(shí)為結(jié)直腸癌患者118列,采用免疫組化(Envison法)及逆轉(zhuǎn)錄聚合酶鏈反應(yīng)(RT-PCR)半定量測(cè)定腫瘤組織、癌旁組織中HPSE及VEGF表達(dá)量,并分析其與一般情況、臨床病理關(guān)系。結(jié)果 HPSE在結(jié)直腸腫瘤組織、癌旁組織中陽性表達(dá)分別為63.6%(75/118)和12.7%(15/118),VEGF在結(jié)直腸腫瘤組織、癌旁組織中陽性表達(dá)分別為71.2%(84/118)和17.8%(21/118),差異均有統(tǒng)計(jì)學(xué)意義(χ2=64.66,P<0.01; χ2=68.09,P<0.01)。結(jié)直腸腫瘤組織、癌旁組織中HPSE mRNA表達(dá)分別為0.223±0.062和0.093±0.026,VEGF mRNA表達(dá)分別為0.584±0.115和0.385±0.064,HPSE mRNA及VEGF mRNA在腫瘤組織表達(dá)水平均較癌旁組織明顯升高(t=15.17,P<0.01; t=11.60,P<0.01)。HPSE、VEGF蛋白陽性表達(dá)和HPSE mRNA、VEGF mRNA表達(dá)量在患者年齡、性別、腫瘤位置、腫瘤大小方面比較,差異均無統(tǒng)計(jì)學(xué)意義(P>0.05); 但在腫瘤分化、腫瘤分期及淋巴轉(zhuǎn)移方面比較,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 HPSE及VEGF在結(jié)直腸腫瘤患者的腫瘤組織中表達(dá)顯著增高,在結(jié)直腸癌的發(fā)生、侵襲及轉(zhuǎn)移中起著重要作用,可成為結(jié)直腸腫瘤患者預(yù)后判斷的基礎(chǔ)。
Abstract:
Objective To study the expression of heparanas(HPSE)and vascular endothelial growth factor(VEGF)in colorectal carcinoma and to investigate its clinical significance.Methods A total of 118 patients with colorectal carcinoma confirmed by surgery and postoperative pathology were selected,the expression of HPSE and VEGF in colorectal neoplasms tissues and in paracancerous tissues were detected by immunohistochemistry and real-time PCR.Their correlation with pathological characteristics and general information was compared.Results The positive expression of HPSE was 63.6%(75/118)in colorectal neoplasms tissues and 12.7%(15/118)in paracancerous tissues, the difference was statistically significant(χ2=64.66,P<0.01).The positive expression of VEGF was 71.2%(84/118)in colorectal neoplasms tissues and 17.8%(21/118)in paracancerous tissues, the difference was statistically significant(χ2=68.09,P<0.01).The expression of HPSE mRNA was 0.223±0.062 in colorectal neoplasms tissues and 0.093±0.026 in paracancerous tissues.The expression of VEGF mRNA was 0.584±0.115 in colorectal neoplasms tissues and 0.385±0.064 in paracancerous tissues.The expression levels of HPSE mRNA and VEGF mRNA in colorectal neoplasms tissues were significantly higher than those in paracancerous tissues(t=15.17,P<0.01; t=11.60,P<0.01).There were no significant differences in the expression of HPSE, VEGF protein and HPSE mRNA,VEGF mRNA in patients with age, gender, neoplasms location and neoplasms size(P>0.05), but the differences were statistically significant in neoplasms differentiation, neoplasms stage and lymph node metastasis(P<0.05).Conclusion The expression of HPSE and VEGF in neoplasms tissues of colorectal cancer patients is significantly increased,and plays an important role in the occurrence, invasion and metastasis of colorectal cancer.It might be used as the basis of screening,prognosis determination of colorectal carcinoma.

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備注/Memo

備注/Memo:
基金項(xiàng)目:南平市指導(dǎo)性科技計(jì)劃項(xiàng)目(N2015D05)1 通信作者,Email:[email protected]
更新日期/Last Update: 1900-01-01