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[1]黃偉煒 張和軍 劉 健 吳 凡 陳木蘭 王麗莉 李娜妮 李重穎.CDK4/6抑制劑聯(lián)合曲妥珠單抗對乳腺癌裸鼠移植瘤抑制和轉(zhuǎn)移的影響[J].福建醫(yī)藥雜志,2020,42(05):133-136.
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CDK4/6抑制劑聯(lián)合曲妥珠單抗對乳腺癌裸鼠移植瘤抑制和轉(zhuǎn)移的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年05期
頁碼:
133-136
欄目:
基礎研究
出版日期:
2020-10-20

文章信息/Info

文章編號:
1002-2600(2020)05-0133-05
作者:
黃偉煒 張和軍1 劉 健 吳 凡 陳木蘭 王麗莉 李娜妮 李重穎
福建省腫瘤醫(yī)院 福建醫(yī)科大學附屬腫瘤醫(yī)院 福建中醫(yī)藥大學教學醫(yī)院乳腺腫瘤內(nèi)科(福州 350014)
關鍵詞:
乳腺癌轉(zhuǎn)移 乳腺癌JIMT-1細胞 裸鼠 動物模型 曲妥珠單抗 哌柏西利
分類號:
R737.9
文獻標志碼:
A
摘要:
目的 觀察曲妥珠單抗、哌柏西利、曲妥珠單抗+哌柏西利對HER-2陽性曲妥珠耐藥細胞裸鼠移植瘤抑瘤效應及阻斷腫瘤轉(zhuǎn)移過程中黏附、突破基底膜、微血管生成作用的差異。方法 建立JIMT-1人乳腺癌細胞裸鼠移植瘤模型,分成曲妥珠單抗、哌柏西利、曲妥珠單抗+哌柏西利和對照組共4組,比較瘤重、抑瘤率。免疫組化法測移植瘤Ki67、血管內(nèi)皮細胞生長因子(VEGF)、基質(zhì)金屬蛋白酶9(MMP9)、CD44v6表達。結(jié)果 與對照組相比,曲妥珠單抗、哌柏西利、曲妥珠單抗+哌柏西利組可明顯抑制移植瘤生長(P<0.0001)。曲妥珠單抗、哌柏西利、曲妥珠單抗+哌柏西利組抑瘤率分別為29.4%、67.0%、76.5%。各組裸鼠腫瘤組織的MMP9、CD44v6低和中高表達的差異無統(tǒng)計學意義(P>0.05),VEGF、Ki67的差異有統(tǒng)計學意義(P<0.05)。用藥后Ki67降低最多的為曲妥珠單抗+哌柏西利組,其后依次為哌柏西利、曲妥珠單抗組。用藥后低表達VEGF比例最高的是曲妥珠單抗+哌柏西利組,其后依次為哌柏西利、曲妥珠單抗組。結(jié)論 曲妥珠單抗+哌柏西利聯(lián)用較單藥更能抑制腫瘤增殖。曲妥珠單抗、哌柏西利無論是單藥還是聯(lián)用,阻止腫瘤黏附、向基質(zhì)侵襲的效果差,聯(lián)用和單藥均能抑制腫瘤血管生成,聯(lián)用的效果更優(yōu)。

參考文獻/References:

[1] Slamon D J, Clark G M, Wong S G, et al.Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene[J].Science, 1987, 235(4785): 177-182.
[2] Puglisi F, Minisini A M, De Angelis C,et al.Overcoming treatment resistance in HER2-positive breast cancer: potential strategies[J].Drugs,2012,72(9):1175-1193.
[3] Scaltriti M, Chandarlapaty S, Prudkin L, et al.Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor[J].Clin Cancer Res, 2010, 16(9): 2688-2695.
[4] Roberts P J, Bisi J E, Strum J C, et al.Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy[J].Journal of the National Cancer Institute, 2012, 104(6):476-487.
[5] Finn R S,Martin M,Rugo H S,et al.Palbociclib and letrozole in advanced breast cancer[J].N Engl J Med,2016,375(20):1925-1936.
[6] Hortobagyi G N, Stemmer S M, Burris H A, et al.Ribociclib as first line therapy for HR-positive, advanced breast cancer[J].N Engl J Med, 2016, 375(18):1738-1748.
[7] Goetz M P, Toi M, Campone M, et al.MONARCH 3: Abemaciclib as initial therapy for advanced breast cancer[J].J Clin Oncol, 2017, 35(32):3638-3646.
[8] Diaz-Rodriguez E, Perez-Pena J, Rios-Luci C, et al.TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells[J].Cancer Lett, 2019, 453: 34-44.
[9] Yang L, Li Y, Bhattacharya A, et al.A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer[J].Sci Transl Med, 2019, 11(476):eaav1620.
[10] 謝韶,丁健,陳奕. CDK抑制劑在抗腫瘤領域的研發(fā)進展[J]. 藥學進展, 2015, 39(10): 734-745.
[11] Herrera Gayol A, Jothy S.Adhesion proteins in the biology of breast cancer: contribution of CD44[J].EXP Mol Pathol,1999,66(2):149-156.
[12] Kleiner D E, Stetler Stevenson W G.Matrix metalloproteinases and metastasis[J].Cancer Chemother Pharmacol, 1999,43(suppl):S42-S51.
[13] Hanahan D,Folkman J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis[J].Cell,1996,86(3):353-364.
[14] Muntasell A, Cabo M, Servitja S, et al.Interplay between natural killer cells and anti-HER2 antibodies: perspectives for breast cancer immunotherapy[J].Front Immunol, 2017, 8:1544.
[15] Loi S, Giobbie-Hurder A, Gombos A, et al.Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer(PANACEA): a single-arm,multicentre, phase 1b-2 trial[J].Lancet Oncol, 2019, 20(3):371-382.
[16] Bang Y J,Giaccone G,Im S A,et al.First-in-human phase 1 study of margetuximab?(MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors[J].Ann Oncol,2017,28(4):855-861.
[17] Varella L, Abraham J, Kruse M.Revisiting the role of bevacizumab in the treatment of breast cancer[J].Semin Oncol,2017,44(4):273-285.

備注/Memo

備注/Memo:
基金項目: 福建省自然科學基金衛(wèi)生聯(lián)合資金面上項目(2018J01265) 1 病理科
更新日期/Last Update: 2020-10-20