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[1]吳燕芳 高 飛 陳志涵 吳晨敏 林 禾.抗Jo-1抗體綜合征15例臨床及肺部影像學(xué)分析[J].福建醫(yī)藥雜志,2020,42(05):1-4.
　WU Yanfang,GAO Fei,CHEN Zhihan,et al.Clinical features and imaging findings in 15 patients with anti-Jo-1 syndrome[J].FUJIAN MEDICAL JOURNAL,2020,42(05):1-4.
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抗Jo-1抗體綜合征15例臨床及肺部影像學(xué)分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年05期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2020-10-20

文章信息/Info

Title:
Clinical features and imaging findings in 15 patients with anti-Jo-1 syndrome
文章編號:
1002-2600(2020)05-0001-04
作者:
吳燕芳 高 飛1 陳志涵 吳晨敏 林 禾
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院風(fēng)濕免疫科(福州 350001)
Author(s):
WU Yanfang;  GAO Fei;  CHEN Zhihan;  WU Chenmin;  LIN He
Department of Rheumatology and Immunology, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
抗Jo-1抗體;  炎性肌病;  臨床特征;  肺部HRCT
Keywords:
anti-Jo-1-antibody;  inflammatory myopathy;  clinical characteristics;  HRCT
分類號:
R593
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 分析15例抗Jo-1抗體綜合征患者的臨床特征、誤診原因及影像學(xué)資料,提高對該病的認(rèn)識。方法收集2017年5月至2019年12月我科收治的71例特發(fā)性炎性肌病(IIM)患者的臨床資料,比較Jo-1陰性組與Jo-1陽性組IIM患者的臨床差異; 分析15例確診抗Jo-1抗體綜合征患者的臨床特點(diǎn)及肺部高分辨計(jì)算機(jī)斷層掃描(HRCT)特征。結(jié)果 1)抗Jo-1抗體綜合征患者臨床表現(xiàn)以肌炎及關(guān)節(jié)炎最常見,發(fā)生率分別為80%(12/15)、60%(9/15); 2)15例(100%)出現(xiàn)間質(zhì)性肺炎(ILD),ILD起病方式以慢性為主(86.7%,13/15),肺部HRCT以基底部(86.7%,13/15)及外周(53.3%,8/15)分布為主; 磨玻璃影(53.3%,8/15)、網(wǎng)格影(46.7%,7/15)及少量胸腔積液(46.7%,7/15)為最常見征象; 3)肺功能檢查以混合性通氣功能障礙為主(80.0%,12/15); 4)15例患者僅5例初診風(fēng)濕免疫科,5例誤診類風(fēng)濕關(guān)節(jié)炎(RA),4例誤診病毒性心肌炎,3例誤診特發(fā)性肺間質(zhì)纖維化(IPF),平均誤診時間6.4個月。結(jié)論 抗Jo-1綜合征以呼吸道和關(guān)節(jié)癥狀起病較多,易誤診為IPF和RA; 早期篩查抗Jo-1抗體及肺部HRCT檢查,利于早期診治,改善預(yù)后。
Abstract:
Objective To improve the understanding of anti Jo-1 syndrome via analyzing the clinical characteristics, misdiagnosis causes and imaging data in 15 patients with this disease.Methods The data of 71 patients with inflammatory myopathy(IIM)were collected from our department from May 2017 to December 2019.The clinical differences between the anti-Jo-1 antibody negative group and the Jo-1 antibody positive group were compared. The clinical manifestations and HRCT features of 15 patients with anti Jo-1 syndrome were analyzed.Results Myositis and arthritis were the most common clinical manifestations, with an incidence of 80%(12/15)and 60%(9/15).Interstitial pneumonia(ILD)occurred in 15(100%), and the onset of ILD was chronic(86.7%, 13/15).The lung abnormalities were predominantly basal(86.7%, 13/15)and peripheral(53.3%, 8/15); ground glass opacities(53.3%, 8/15), reticulations(46.7%, 7/15)and few pleural effusion(46.7%, 7/15)were the most common signs; mixed ventilation dysfunction was the main sign in pulmonary function examination(80.0%, 12/15).Only five patients were initially diagnosed in Rheumatology Department, five patients were misdiagnosed as rheumatoid arthritis(RA), four as viral myocarditis, and three as idiopathic pulmonary pulmonary fibrosis(IPF).Conclusion Anti Jo-1 syndrome usually starts with respiratory and joint symptoms, which is most likely to be misdiagnosed as RA and IPF.Early detection of anti Jo-1 antibody and lung HRCT is conducive to early diagnosis, treatment, and improvement of prognosis.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金項(xiàng)目(2017J01170)1 通信作者, Email:[email protected]
更新日期/Last Update: 2020-10-20