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[1]楊國華 鄭圣斌 林彩鋒 黃若磊.腫瘤相關(guān)成纖維細胞經(jīng)FGF19/FGFR4信號軸調(diào)控結(jié)腸癌細胞生長的實驗研究[J].福建醫(yī)藥雜志,2020,42(04):136-139.
　YANG Guohua,ZHENG Shengbin,LIN Caifeng,et al.Experimental study on CAF regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19[J].FUJIAN MEDICAL JOURNAL,2020,42(04):136-139.
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腫瘤相關(guān)成纖維細胞經(jīng)FGF19/FGFR4信號軸調(diào)控結(jié)腸癌細胞生長的實驗研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年04期
頁碼:
136-139
欄目:
基礎(chǔ)研究
出版日期:
2020-08-20

文章信息/Info

Title:
Experimental study on CAF regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19
文章編號:
1002-2600(2020)04-0136-04
作者:
楊國華 鄭圣斌 林彩鋒 黃若磊
福建醫(yī)科大學(xué)省立臨床學(xué)院 福建省立金山醫(yī)院普外科(福州 350007)
Author(s):
YANG Guohua;  ZHENG Shengbin;  LIN Caifeng;  HUANG Ruolei.
Department of General Surgery, Provincial Jinshan Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350007,China
關(guān)鍵詞:
腫瘤相關(guān)成纖維細胞;  FGF19;  FGFR4;  結(jié)腸癌;  生長
Keywords:
CAF;  FGF19;  FGFR4;  colorectal cancer;  growth
分類號:
R735.3
文獻標志碼:
B
摘要:
目的 探討腫瘤相關(guān)成纖維細胞(CAF)通過FGFR4/FGF19信號軸調(diào)控結(jié)直腸癌生長可能機制。方法 將研究對象分為3組,分別是細胞組、細胞+NF組、細胞+CAF組。繪制各組癌細胞生長曲線,采用ELISA法檢測細胞外FGF19因子濃度變化。 結(jié)果 癌細胞與CAF共培養(yǎng)后,癌細胞生長率明顯提高,與其他組比較,差異有統(tǒng)計學(xué)意義(P<0.05); 細胞外FGF19因子濃度明顯提高,與其他組比較,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 CAF通過促進結(jié)腸癌細胞自分泌FGF19因子,促進癌細胞分裂生長。
Abstract:
Objective To explore the possible mechanism of cancer associated fibroblast(CAF)regulating the growth of colorectal cancer through the signal axis of fibroblast growth factor 4/fibroblast growth factor 19. Methods The experiment was divided into three groups, including cancer cell group, cancer cell+NF group, cancer cell+CAF group. The growth curve of each group was drawn. The changes of extracellular fibroblast growth factor 19 were detected by ELISA. Results After co-culture of cancer cells with CAF, the growth rate of cancer cells was significantly increased, compared with other groups(P<0.05); the concentration of extracellular fibroblast growth factor 19 was significantly increased, compared with other groups(P<0.05). Conclusion CAF can promote the autocrine of fibroblast growth factor 19 and promote the growth of cancer cells.

參考文獻/References:

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相似文獻/References:

[1]楊國華,鄭圣斌,游治杰,等.FGF19因子促進結(jié)腸癌細胞增殖及遷移的機制研究[J].福建醫(yī)藥雜志,2024,46(05):56.[doi:10.20148/j.fmj.2024.05.016]

更新日期/Last Update: 2020-08-20