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[1]鄭 田 林 帆.纖維蛋白原與清蛋白比值指數(shù)對(duì)胃間質(zhì)瘤危險(xiǎn)程度分級(jí)的預(yù)測(cè)價(jià)值[J].福建醫(yī)藥雜志,2020,42(04):9-13.
　ZHENG Tian,LIN Fan..Predictive value of fibrinogen-to-albumin ratio index for risk classification of gastric stromal tumor[J].FUJIAN MEDICAL JOURNAL,2020,42(04):9-13.
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纖維蛋白原與清蛋白比值指數(shù)對(duì)胃間質(zhì)瘤危險(xiǎn)程度分級(jí)的預(yù)測(cè)價(jià)值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年04期
頁(yè)碼:
9-13
欄目:
臨床研究
出版日期:
2020-08-20

文章信息/Info

Title:
Predictive value of fibrinogen-to-albumin ratio index for risk classification of gastric stromal tumor
文章編號(hào):
1002-2600(2020)04-0009-05
作者:
鄭 田 林 帆1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院老年科 福建省老年醫(yī)學(xué)中心(福州 350001)
Author(s):
ZHENG Tian;  LIN Fan.
Department of Geriatric Medicine, Fujian Provincial Center for Geriatrics,Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou, Fujian 350001, China
關(guān)鍵詞:
胃間質(zhì)瘤;  纖維蛋白原與清蛋白比值指數(shù);  危險(xiǎn)程度分級(jí)
Keywords:
gastric stromal tumor;  fibrinogen-to-albumin ratio index;  risk classification
分類(lèi)號(hào):
R735.2
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討纖維蛋白原與清蛋白比值指數(shù)(FARI)對(duì)胃間質(zhì)瘤危險(xiǎn)程度的預(yù)測(cè)價(jià)值。方法 回顧性收集在本院收治的經(jīng)外科手術(shù)或內(nèi)鏡下切除、術(shù)后病理及免疫組化確診為胃間質(zhì)瘤的患者共208例。根據(jù)術(shù)后病理分為低危組和高危組,分析術(shù)前臨床資料與胃間質(zhì)瘤危險(xiǎn)程度的關(guān)系。結(jié)果 單因素分析顯示,胃間質(zhì)瘤危險(xiǎn)程度組間臨床癥狀、中性分葉核計(jì)數(shù)、血小板計(jì)數(shù)、NLR、PLR、清蛋白、纖維蛋白原、FARI、三酰甘油、HDL-C、瘤細(xì)胞形態(tài)、核分裂象計(jì)數(shù)、腫瘤大小差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。logistic回歸分析顯示,FARI[OR=1.18; 95%CI(1.03,1.35); P<0.05]及HDL-C[OR=0.18; 95%CI(0.09,0.33); P<0.01]是胃間質(zhì)瘤危險(xiǎn)程度的獨(dú)立危險(xiǎn)因素。受試者工作特征(ROC)曲線分析結(jié)果顯示,FARI曲線下面積為0.711,最佳界限值為7.86%時(shí),預(yù)測(cè)胃間質(zhì)瘤危險(xiǎn)程度的靈敏度為0.551,特異度為0.806。結(jié)論 FARI可作為胃間質(zhì)瘤危險(xiǎn)程度的獨(dú)立預(yù)測(cè)指標(biāo),在危險(xiǎn)程度分級(jí)的早期預(yù)測(cè)及預(yù)后預(yù)估中有一定的指導(dǎo)意義。
Abstract:
Objective To investigate the value of fibrinogen-to-albumin ratio index(FARI)in predicting the risk classification of gastric stromal tumor.Methods A total of 208 patients with gastric stromal tumor diagnosed by postoperative pathology and immunohistochemistry after surgical or endoscopic resection were collected retrospectively.According to postoperative pathology, the patients were divided into low risk group and high risk group, and the relationship between preoperative clinical data and the risk of gastric stromal tumor was analyzed.Results Single factor analysis showed that the differences of clinical symptoms, neutral points leaf nuclear count, platelet count, NLR, PLR, albumin, fibrinogen, FARI, triglyceride, high-density lipoprotein cholesterol,tumor cell morphology, fission like counting, tumor size had statistical significance(P<0.05)between the two groups.Logistic regression analysis showed that FARI[OR=1.18; 95%CI(1.03,1.35); P<0.05] and HDL-C[OR=0.18; 95%CI(0.09,0.33); P<0.01] were independent risk factors for the risk degree of gastric stromal tumor.The ROC curve analysis showed that when the area under the FARI curve was 0.711 and the optimal threshold value was 7.86%, the sensitivity and specificity for predicting the risk of gastric stromal tumor were 0.551 and 0.806.Conclusion FARI can be used as an independent predictor of the risk degree of gastric stromal tumors,and has a certain guiding significance in the early prediction of risk classification and prognosis prediction.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建醫(yī)科大學(xué)啟航基金(2017XQ1140)1 通信作者,福建省立醫(yī)院干部特診二科
更新日期/Last Update: 2020-08-20