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[1]林樹春 胡曉華 賴海春 林 勤.頭頸部鱗狀細胞癌患者體內免疫抑制性細胞因子與調節(jié)性T細胞的表達分析[J].福建醫(yī)藥雜志,2020,42(03):23-27.
　LIN Shuchun,HU Xiaohua,LAI Haichun,et al.Analysis of expression of immunosuppressive cytokines and regulatory T cells in patients with head and neck squamous cell carcinoma[J].FUJIAN MEDICAL JOURNAL,2020,42(03):23-27.
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頭頸部鱗狀細胞癌患者體內免疫抑制性細胞因子與調節(jié)性T細胞的表達分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年03期
頁碼:
23-27
欄目:
臨床研究
出版日期:
2020-07-04

文章信息/Info

Title:
Analysis of expression of immunosuppressive cytokines and regulatory T cells in patients with head and neck squamous cell carcinoma
文章編號:
1002-2600(2020)03-0023-05
作者:
林樹春 胡曉華 賴海春 林 勤
福建醫(yī)科大學附屬協(xié)和醫(yī)院耳鼻咽喉科(福州 350001)
Author(s):
LIN Shuchun; HU Xiaohua; LAI Haichun; LIN Qin.
Department of Otorhinolaryngology,the Affiliated Union Hospital,Fujian Medical University,Fuzhou,Fujian 350001,China
關鍵詞:
頭頸部;  惡性腫瘤;  細胞因子;  T淋巴細胞;  免疫抑制
Keywords:
head and neck;  malignant tumors;  cytokines;  T lymphocytes;  immunosuppression
分類號:
R739.91
文獻標志碼:
B
摘要:
目的 探討頭頸部鱗狀細胞癌(HNSCC)體內免疫抑制性細胞因子與調節(jié)性T細胞(Treg)的相互關系。方法 使用ELISA方法檢測HNSCC患者及健康志愿者外周血血清中的IL-10、TGF-β1、INF-γ含量,同時用流式細胞術檢測HNSCC患者及健康志愿者外周血中的CD4+Foxp3+Treg和GARP+Foxp3+Treg含量,并分析TGF-β1含量與CD4+Foxp3+Treg、GARP+Foxp3+Treg含量的相關性。結果 與健康志愿者組比較,HNSCC患者外周血中的IFN-γ含量減少,IL-10和TGF-β1含量明顯增加,差異均有統(tǒng)計學意義(t=4.863,P=0.000; t=4.544,P=0.000; t=2.451,P=0.018)。與健康志愿者組比較,HNSCC患者外周血中的CD4+Foxp3+Treg比例和GARP+Foxp3+Treg比例均增加(t=4.613,P=0.000; t=4.621,P=0.000)。CD4+Foxp3+Treg、GARP+Foxp3+Treg比例升高與高血漿水平TGF-β1之間均呈正相關(r=0.67,P<0.001; r=0.81,P<0.001)。結論 HNSCC患者體內CD4+Foxp3+Treg及GARP+Foxp3+Treg比例增加,伴隨IFN-γ減少及相應IL-10和TGF-β1明顯增加,這些因素相互聯(lián)系、相互作用,可能造成HNSCC體內腫瘤免疫抑制。
Abstract:
Objective To explore the relationship between immunosuppressive cytokines and regulatory T cells(Tregs)in head and neck squamous cell carcinoma(HNSCC).Methods The serum levels of IL-10, TGF-β1, and INF-γ in the peripheral blood of HNSCC patients and healthy volunteers were detected by ELISA, and the CD4+Foxp3+Treg and GARP+Foxp3+Treg in peripheral blood of HNSCC patients and healthy volunteers were detected by flow cytometry.Then the correlations between TGF-β1 and CD4+Foxp3+Treg, TGF-β1 and GARP+Foxp3+Treg were analyzed.Results Compared with healthy volunteers, the IFN-γ levels in HNSCC patients decreased, and the levels of IL-10 and TGF-β1 increased significantly, the differences were statistically significant(t=4.863, P=0.000; t=4.544, P=0.000; t=2.451, P=0.018).Compared with healthy volunteers, the proportion of CD4+Foxp3+Treg and GARP+Foxp3+Treg in peripheral blood of patients with HNSCC increased(t=4.613, P=0.000; t=4.621, P=0.000).CD4+Foxp3+Treg and GARP+Foxp3+Treg were positively correlated with high plasma levels of TGF-β1(r=0.67,P<0.001; r=0.81,P<0.001).Conclusion The proportions of CD4+Foxp3+Treg and GARP+Foxp3+Treg increase in HNSCC patients, with the decrease of IFN-γ and the corresponding increase of IL-10 and TGF-β1.These factors are related and interact with each other, which may cause tumor immunosuppression in HNSCC.

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備注/Memo

備注/Memo:
基金項目:福建省自然科學基金衛(wèi)生聯(lián)合資金項目(2016J01460)
更新日期/Last Update: 2020-07-04