80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]王佳蓉 邱連升 陳翊民 陳敏云.舌下含服標(biāo)準(zhǔn)化塵螨滴劑治療兒童變應(yīng)性鼻炎的療效及機(jī)制研究[J].福建醫(yī)藥雜志,2020,42(01):19-22.
　WANG Jiarong,QIU Liansheng,CHEN Yimin,et al.Research on the efficacy and mechanism of sublingual standardized dust mite drops allergen vaccine to allergic rhinitis in children[J].FUJIAN MEDICAL JOURNAL,2020,42(01):19-22.
點(diǎn)擊復(fù)制

舌下含服標(biāo)準(zhǔn)化塵螨滴劑治療兒童變應(yīng)性鼻炎的療效及機(jī)制研究()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年01期
頁碼:
19-22
欄目:
臨床研究
出版日期:
2020-03-30

文章信息/Info

Title:
Research on the efficacy and mechanism of sublingual standardized dust mite drops allergen vaccine to allergic rhinitis in children
文章編號:
1002-2600(2020)01-0019-04
作者:
王佳蓉 邱連升1 陳翊民 陳敏云
福建醫(yī)科大學(xué)附屬第二醫(yī)院耳鼻咽喉科(泉州 362000)
Author(s):
WANG Jiarong; QIU Liansheng; CHEN Yimin; CHEN Minyun.
Department of Otorhinolaryngology, the Second Affiliated hospital of Fujian Medical University, Quanzhou,Fujian 362000, China
關(guān)鍵詞:
鼻炎; 變應(yīng)性; 持續(xù)性;  脫敏法; 免疫;  T淋巴細(xì)胞; 調(diào)節(jié)性;  Thl7細(xì)胞
Keywords:
rhinitis; allergic; persistent;  desensitization;  immunologic;  T-lymphocytes; regulatory;  Thl7 cells
分類號:
R765
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討舌下含服標(biāo)準(zhǔn)化塵螨滴劑特異性免疫(SLIT)治療兒童變應(yīng)性鼻炎(AR)的療效和可能機(jī)制。方法 選取我院確診為持續(xù)性變應(yīng)性鼻炎的患兒80例,根據(jù)患兒家屬意愿分為標(biāo)準(zhǔn)化塵螨滴劑舌下含服特異性免疫治療組(觀察組)與常規(guī)藥物治療(對照組),每組40例。采用癥狀視覺模擬量表評分(VAS)、用藥評分法評定療效,比較治療前與治療1年后的VAS評分與用藥評分。采用流體細(xì)胞技術(shù)檢測治療前、治療1年后外周血輔助性T細(xì)胞17(Th17)、調(diào)節(jié)性T細(xì)胞(Treg)的細(xì)胞比例。 結(jié)果 觀察組治療1年后VAS評分及用藥評分分別為(2.70±1.08)、(1.05±0.81),較治療前的(7.65±1.23)、(3.58±0.96)明顯下降,差異均有統(tǒng)計(jì)學(xué)意義(t=31.35,t=13.83; 均P<0.05)。對照組治療1年后VAS評分為(3.34±1.22),較治療前的(7.35±1.03)下降,差異有統(tǒng)計(jì)學(xué)意義(t=14.64,P<0.05); 對照組治療前后用藥評分差異無統(tǒng)計(jì)學(xué)意義(t=0.80,P=0.43)。觀察組治療1年后外周血Treg細(xì)胞比例顯著增高,Th17細(xì)胞比例降低,差異有統(tǒng)計(jì)學(xué)意義(tTreg=20.28,tTh17=9.41,均P<0.05),而對照組治療前后Treg和Th17細(xì)胞比例差異無統(tǒng)計(jì)學(xué)意義(均P>0.05)。結(jié)論 兩組均能改善AR 患者癥狀,而SLIT 能減少患兒藥物用量,其療效優(yōu)于常規(guī)藥物治療。SLIT治療AR的機(jī)制可能是能夠誘導(dǎo)Treg細(xì)胞的產(chǎn)生,抑制Thl7細(xì)胞增殖,上調(diào)Treg/Thl7比例,使Treg和Thl7細(xì)胞亞群比例和功能的平衡復(fù)位,最終達(dá)到免疫耐受。
Abstract:
Objective The study was designed to analyze the efficacy and investigate the possible mechanism of sublingual standardized dust mite drops allergen vaccine to allergic rhinitis(AR)in children.Methods The study was performed in the Second Affiliated hospital of Fujian Medical University, involving 80 children patients with persistent AR,of whom 40 children patients received sublingual immunotherapy(SLIT)and pharmacotherapy(observation group)after their guardians, approval and 40 children patients received only pharmacotherapy(control group).All patients were allergic to dust mites.Symptom and medication scores were recorded before treatment and after treatment one year. Treg cells and Thl7 cells were measured by flow cytometry.Results VAS score and medication score in the observation group after one year of treatment were(2.70±1.08)and(1.05±0.81), respectively, which were significantly lower than those before treatment(7.65±1.23)and(3.58±0.96), with statistically significant differences(t=31.35, t=13.83).All P<0.05).The VAS score in the control group was(3.34±1.22)after one year of treatment, which was lower than that before treatment(7.35±1.03), and the difference was statistically significant(t=14.64, P<0.05),and there was no significant difference in medication scores before and after treatment(t=0.80, P=0.43). The proportion of Thl7 cells in peripheral blood mononuclear cells decreased in the observation group, whereas the proportion of Treg cells increased(tTreg=20.28,tTh17=9.41; both P<0.05),but not in the control group.Conclusion Both SLIT and pharmacotherapy can improve symptoms of AR, but SLIT can also reduce medication use.The effect of immunotherapy is better than drug treatment alone.The proportion of blood Thl7 cells in peripheral blood mononuclear cells decreases in patients treated with SLIT, whereas the proportion of Treg cells increases,the proportion of Treg/Thl7 is upregulated to restore the balance of the proportion and function of Treg and Thl7 cell subsets and finally achieves immune tolerance.

參考文獻(xiàn)/References:

[1] 儲俊才,程雷.變應(yīng)性鼻炎變應(yīng)原免疫治療新指南[J].中國中西醫(yī)結(jié)合耳鼻咽喉科雜志,2018,26(3):161-162.
[2] 劉莉,劉爭,梁耕田,等.Treg/Th17在變應(yīng)性鼻炎患者血液中的意義[J].現(xiàn)代免疫學(xué),2015,35(2):136- 140.
[3] Gu Z W,Wang Y X,Cao Z W.Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2,Th9,and Th17 responses and increasing the Treg response in a murine model [J].Oncotarget, 2017,8(9):14314-14324.
[4] 中華耳鼻咽喉頭頸外科雜志編輯委員會鼻科組,中華醫(yī)學(xué)會耳鼻咽喉頭頸外科學(xué)分會鼻科學(xué)組.變應(yīng)性鼻炎診斷和治療指南(2015 年,天津)[J]. 中華耳鼻咽喉頭頸外科雜志,2016,51(1): 6-24.
[5] Bousquet P J,Combescure C, Neukirch F, et al.Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines[J].Allergy,2007,62(4):367-372.
[6] Pfaar O, Demoly P, Gerth van Wijk R, et al.Recommen-dations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper[J],Allergy,2014,69(7):854-867.
[7] 王潔,周麗楓,陳彥秋,等.廣州地區(qū)兒童變應(yīng)性鼻炎患者吸入變應(yīng)原譜分析[J].臨床耳鼻咽喉頭頸外科雜志,2012,26(22):1026-1029.
[8] 宋薇薇,林小平,仲歡歡,等.遼寧地區(qū)變應(yīng)性鼻炎患者吸入變應(yīng)原譜分析[J].中華臨床免疫和變態(tài)反應(yīng)雜志,2011,5(4):263-267.
[9] Zhang Y M,Zhang J, Liu S L, et al.Prevalence and associated risk factors of allergic rhinitis in preschool children in Beijing [J]. Laryngoscope, 2013,123(1):28-35.
[10] Bao Y, Chen J, Cheng L, et al.Chinese Guideline on allergen immunotherapy for allergic rhinitis [J]. J Thorac Dis, 2017, 9(11): 4607-4650.
[11] Agrawal D K, Shao Z.Pathogenesis of allergic airway inflammation [J].Curr Allergy Asthma Pep, 2010,10(1):39-48.
[12] Wei P,Nu G N,Kang N Y, et al.An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Thl7 response in allergic rhinitis patients [J].Lab 1nvest, 2014, 94(5): 528-535.
[13] 瞿申紅,李敏,黃永堅(jiān),等.變應(yīng)原和糖皮質(zhì)激素對變應(yīng)性鼻炎患者外周血Thl7細(xì)胞及其轉(zhuǎn)錄因子RORγt的作用[J].中華耳鼻咽喉頭頸外科雜志,2009,44(12):996-1000.
[14] Peterson R A.Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression [J]. Toxicol Pathol, 2012, 40(2): 186-204.
[15] Akdis C A, Akdis M.Mechanisms of allergen-specific immunotherapy [J]. J Allergy Clin Immunol,2011,127(1):18-27.
[16] Meiler F, Klunker S, Zimmermann M, et al.Distinct regula-tion of IgE,IgG4 and IgA by T regulatory cells and toll-like receptors [J]. Allergy, 2008,63(11):1455-1463.

備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金資助項(xiàng)目(2016J01521)1 通信作者,Email:[email protected]
更新日期/Last Update: 2020-03-30