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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:

41

期數(shù):

2019年06期

頁碼:

8-11

欄目:

臨床研究

出版日期:

2019-12-25

文章信息/Info

Title:

Correlation analysis between food intolerance and hepatogenic diarrhea

文章編號:

1002-2600(2019)06-0008-04

作者:

莊 瑩 林志輝¹

福建省立醫(yī)院消化內(nèi)科(福州 350001)

Author(s):

ZHUANG Ying; LIN Zhihui.

Department of Gastroenterology,Fujian Provincial Hospital,Fuzhou,Fujian 350001,China

關(guān)鍵詞:

食物不耐受;  肝源性腹瀉;  腸肝軸

Keywords:

food intolerance;  hepatogenic diarrhea;  gut-liver axis

分類號:

R442.2

文獻(xiàn)標(biāo)志碼:

B

摘要:

目的 探討食物不耐受與肝源性腹瀉的關(guān)系。方法 收集慢性肝病患者895例,比較肝源性腹瀉在慢性肝炎(n=408)、肝硬化代償(n=204)和肝硬化失代償(n=283)3組間的差異; 比較肝硬化患者中,食物不耐受檢測陽性率、食物不耐受中度敏感陽性率、食物不耐受高度敏感陽性率、多種食物不耐受發(fā)生率這4個指標(biāo)在肝功能Child-Pugh分級A(n=241)、B(n=133)、C(n=113)3組間的差異; 比較上述4個指標(biāo)在合并和無合并肝源性腹瀉的慢性肝病患者中的差異,logistic回歸分析食物不耐受與肝源性腹瀉的相關(guān)性。結(jié)果 慢性肝炎、肝硬化代償和肝硬化失代償3組間肝源性腹瀉發(fā)生率比較差異有統(tǒng)計學(xué)意義(χ²=45.693,P<0.001); 食物不耐受檢測陽性率、食物不耐受中度敏感陽性率、食物不耐受高度敏感陽性率、多種食物不耐受發(fā)生率在肝功能Child-Pugh分級A、B、C 3組間比較差異有統(tǒng)計學(xué)意義(χ²=31.559,χ²=14.132,χ²=36.674,χ²=38.405,P均<0.001); 慢性肝炎、肝硬化代償和肝硬化失代償3組中,合并肝源性腹瀉者食物不耐受檢測陽性率均高于無肝源性腹瀉組(χ²=22.183,χ²=12.272,χ²=16.495,P均<0.001); 食物不耐受檢測陽性均是慢性肝炎、肝硬化代償和肝硬化失代償發(fā)生肝源性腹瀉的獨立危險因素[OR=4.656,95%CI(2.346,9.243),P<0.001; OR=3.707,95%CI(1.729,7.946),P<0.001; OR=2.936,95%CI(1.730,4.984),P=0.001)]。 結(jié)論 食物不耐受與肝源性腹瀉存在一定關(guān)聯(lián)。

Abstract:

Objective To investigate the relationship between food intolerance and hepatogenic diarrhea. Methods A total of 895 cases with chronic liver diseases were collected.The difference of the incidence rate of hepatogenic diarrhea among patients with chronic hepatitis(n=408),liver cirrhosis compensation(n=204)and liver cirrhosis decompensation(n=283)was compared.The differences of the positive rates of food intolerance,food intolerance medium sensitivity,food intolerance high sensitivity and multiple food intolerance were compared among patients with liver cirrhosis Child-Pugh grade A(n=241), B(n=133)and C(n=113).The differences of the positive rates of food intolerance,food intolerance medium sensitivity,food intolerance high sensitivity and multiple food intolerance were compared between patients with and without hepatogenic diarrhea.The correlation between food intolerance and hepatogenic diarrhea was analysed by binary logistic regression.Results There was significant difference in the incidence rate of hepatogenic diarrhea among patients with chronic hepatitis,liver cirrhosis compensation and liver cirrhosis decompensation(χ²=45.693,P<0.001).There were significant differences in the positive rates of food intolerance,food intolerance medium sensitivity rate,food intolerance high sensitivity and multiple food intolerance positive rate among patients with liver cirrhosis Child-Pugh grade A,B and C(χ²=31.559,χ²=14.132,χ²=36.674,χ²=38.405,P<0.001).The positive rate of food intolerance in patients of liver diseases with hepatogenic diarrhea was higher than that without hepatogenic diarrhea(χ²=22.183,χ²=12.272,χ²=16.495,P<0.001).The positive detection of food tolerance was an independent risk factor for chronic hepatitis,liver cirrhosis compensation and liver cirrhosis decompensation[OR=4.656,95%CI(2.346,9.243),P<0.001; OR=3.707,95%CI(1.729,7.946),P<0.001; OR=2.936,95%CI(1.730,4.984),P=0.001)].Conclusion There is a correlation between food intolerance and hepatogenic diarrhea.

備注/Memo

備注/Memo:

基金項目:泉州市科技計劃項目(2018Z158)

常用功能

更新日期/Last Update: 2019-12-25