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[1]鄭 竑 陳學(xué)生 林 偉.TiO2納米管陣列/介孔羥基磷灰石復(fù)合型藥物載體的構(gòu)建及藥物緩釋研究[J].福建醫(yī)藥雜志,2019,41(03):8-11.
　ZHENG Hong,CHEN Xuesheng,LIN Wei..Construction and drug sustained release of TiO2 nanotube array/mesoporous hydroxyapatite composite drug carrier[J].FUJIAN MEDICAL JOURNAL,2019,41(03):8-11.
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TiO2納米管陣列/介孔羥基磷灰石復(fù)合型藥物載體的構(gòu)建及藥物緩釋研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期數(shù):
2019年03期
頁(yè)碼:
8-11
欄目:
臨床研究
出版日期:
2019-02-20

文章信息/Info

Title:
Construction and drug sustained release of TiO2 nanotube array/mesoporous hydroxyapatite composite drug carrier
文章編號(hào):
1002-2600(2019)03-0008-04
作者:
鄭 竑 陳學(xué)生 林 偉1
福建省福州市第二醫(yī)院骨科(福州 350007)
Author(s):
ZHENG Hong; CHEN Xuesheng; LIN Wei.
Department of Orthopaedics,Fuzhou Municipal Second Hospital, Fuzhou,Fujian 350007,China
關(guān)鍵詞:
骨科鈦板;  TiO2納米管陣列;  介孔羥基磷灰石;  阿侖磷酸鈉;  緩釋
Keywords:
orthopedic titanium plate;  TiO2 nanotube array;  mesoporous hydroxyapatite;  alendronate sodium;  sustained release
分類(lèi)號(hào):
R68
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 構(gòu)建一種骨科鈦板表面TiO2納米管陣列/介孔羥基磷灰石(m-HA)復(fù) 合型藥物載體,考察阿侖膦酸鈉(ALN)在其上的緩釋性能。方法 利用X射線(xiàn)衍射(XRD)、掃描電鏡 (SEM)、透射電鏡(TEM)分別表征TiO2納米管陣列及TiO2納米管陣 列/m-HA復(fù)合型藥物載體的形貌,并測(cè)定其上負(fù)載ALN的緩釋。結(jié)果 成功構(gòu)建了穩(wěn)定的 TiO2納米管陣列/m-HA復(fù)合型藥物載體,相對(duì)于TiO2納米管陣列具有更 大的藥物擔(dān)載量。同時(shí)負(fù)載在TiO2納米管陣列中的ALN在第3 d時(shí)釋放量即達(dá) (88.06±6.27)%,從第5 d開(kāi)始,藥物釋放基本完畢,8 d后的總釋放率為 (94.91±8.51)%; 負(fù)載在TiO2納米管陣列/m-HA復(fù)合型藥物載體中的ALN在第3 d時(shí)的釋放量?jī)H為(66.51±5.37)%,且在后續(xù)的幾天里保持持續(xù)緩慢釋放藥物,8 d后總釋放 率達(dá)到(97.31±8.22)%。結(jié)論 TiO2納米管陣列/m-HA復(fù)合型藥物載體比單純的 TiO2納米管陣列具有更大的藥物擔(dān)載量,同時(shí)緩釋性能更好。
Abstract:
Objective To construct a TiO2 nanotube array/mesoporous hydroxyapatite(m-HA)composite drug carrier on the surface of orthopedic titanium plate, and investigate the sustained release of alendronate sodium(ALN)on its performance.Methods X-ray diffraction(XRD), scanning electron microscopy(SEM)and transmission electron microscopy(TEM)were used to characterize the morphology of TiO2 nanotube array and TiO2 nanotube array/m-HA composite drug carriers.The sustained release of the loaded ALN was measured.Results Stable TiO2 nanotube array/m-HA composite drug carriers were successfully constructed, which had a larger drug loading capacity than the TiO2 nanotube array.The release rate of ALN loaded on the TiO2 nanotube array at the 3rd days was(88.06±6.27)%, the drug release was almost completed from the 5th day, and the total release rate after eight days was(94.91±8.51)%.The release rate of ALN loaded on the TiO2 nanotube array/m-HA composite drug carriers was only(66.51±5.37)% at the 3rd days, the sustained release of the drug continued for the next few days, and the total release rate reached (97.31±8.22)% after eight days.Conclusion The TiO2 nanotube array/m-HA composite drug carrier has a larger drug loading than the pure TiO2 nanotube array, and the sustained release performance is better.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項(xiàng)目:2018年福建省自然科學(xué)基金面上項(xiàng)目(2018J01357) 1 通信作者,Email:[email protected]
更新日期/Last Update: 2019-02-20