[1]郭暉[],陳玲玲[],何嘏娜[],等.補(bǔ)腎化痰方對(duì)多囊卵巢綜合征患者M(jìn)MPs及IGFBP-1表達(dá)變化的影響[J].福建醫(yī)藥雜志,2017,39(3):107-109.
　GUO Hui[],CHEN Lingling[],HE Guna[],et al.Effect of MMPs and IGFBP-1 expression in polycystic ovary syndrome treated by Bushen Huatan recipe[J].FUJIAN MEDICAL JOURNAL,2017,39(3):107-109.
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補(bǔ)腎化痰方對(duì)多囊卵巢綜合征患者M(jìn)MPs及IGFBP-1表達(dá)變化的影響

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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

Title:: Effect of MMPs and IGFBP-1 expression in polycystic ovary syndrome treated by Bushen Huatan recipe

作者:: 郭暉[1]; 陳玲玲[1]; 何嘏娜[1]; 陳溶微[2]; 福建省福州市第二醫(yī)院婦科福州350003福建省福州市第二醫(yī)院檢驗(yàn)科福州350003

摘要:: 目的研究補(bǔ)腎化痰中藥對(duì)多囊卵巢綜合征患者血清IGFBP-1及MMPs水平的影響,分析補(bǔ)腎化痰中藥對(duì)PCOS改善的作用機(jī)制.方法對(duì)PCOS患者進(jìn)行中藥治療、西藥治療、中西醫(yī)聯(lián)合治療,采用臨床癥狀評(píng)分來(lái)評(píng)價(jià)中醫(yī)證候治療效果,采用酶聯(lián)免疫檢測(cè)法檢測(cè)患者治療前后血清中MMP-2、MMP-9和IGFBP-1的水平.結(jié)果補(bǔ)腎化痰方能取得與西藥達(dá)英-35相同的中醫(yī)證候治療效果,中西醫(yī)聯(lián)合治療的效果最佳,能夠在顯著降低患者體內(nèi)MMP-2、MMP-9的水平的同時(shí)提高患者體內(nèi)IGFBP-1的水平.結(jié)論補(bǔ)腎化痰中藥對(duì)PCOS的改善可能與MMP-2、MMP-9和IGFBP-1的水平相關(guān).

Abstract:: Objective To investigate the effects of MMPs and IGFBP-1 expression in polycystic ovary syndrome treated by Bushen Huatan recipe and analyze the mechanism of action of Bushen Huatan recipe for PCOS improving.Methods PCOS patients were treated with traditional Chinese medicine,western medicine,combined Chinese and western medicine.The efficacy of the treatment of syndromes were evaluated by the clinical symptom scores,the MMP-2,MMP-9 and IGFBP-1 level before and after treatment in patients were detected by ELISA.Results Bushen Huatan recipe could achieve the same as the western medicine taie-35 syndromes treatment effect.Combined Chinese and western medicine treatment effect was best,and it could significantly reduce the body of the level of MMP-2 and MMP-9,at the same time,improve the IGFBP-1 level.Conclusion Bushen Huatan recipe may be closely related to the level of MMP-2,MMP-9 and IGFBP-1 for PCOS treatment.

更新日期/Last Update: 1900-01-01