早期饑荒暴露與成年后蛋白尿的風(fēng)險(xiǎn)的關(guān)聯(lián)研究-《福建醫(yī)藥雜志》

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

Title:: Exposure to the Chinese famine in early life and the risk of microalbuminuria in adulthood

作者:: 林苗[1]; 溫俊平[2]; 黃惠彬[2]; 梁繼興[2]; 李連濤[2]; 林麗香[2]; 陳剛[2]; 福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院福建省立醫(yī)院腎內(nèi)科福州350001福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院福建省立醫(yī)院內(nèi)分泌科福州350001

Author(s):: LIN Miao[1]; WEN Junping[2]; HUANG Huibin[2]; LIANG Jixing[2]; LI Liantao[2]; LIN Lixiang[2]; CHEN Gang[2]

摘要:: 目的研究1959-1961年自然災(zāi)害饑荒暴露與成年后微量白蛋白尿發(fā)生風(fēng)險(xiǎn)的相關(guān)性,探討胎兒和兒童期營(yíng)養(yǎng)缺乏是否為成年后白蛋白尿發(fā)生的危險(xiǎn)因素.方法2011年6月至2012年1月在福建寧德及武夷山地區(qū)進(jìn)行普通人群篩查,共入組4504例于1953-1964年出生的受檢者.按照出生時(shí)間分為4個(gè)組.1959-1961年出生者為胎兒期饑荒暴露組,1956-1958年出生者為兒童早期暴露組,1953-1955年出生者為兒童晚期暴露組,1962-1964年出生者為非暴露組.使用多元Logistics回歸分析分析不同饑荒暴露組與非暴露組成年后微量白蛋白尿的校正比值比(OR).結(jié)果以非暴露組為對(duì)照組,經(jīng)校正年齡、體質(zhì)量指數(shù)(BMI)、收縮壓、空腹血糖、吸煙、飲酒等因素后,結(jié)果顯示女性受試者胎兒期、兒童早期和兒童晚期饑荒暴露者成年后發(fā)生微量白蛋白尿的風(fēng)險(xiǎn)較非饑荒暴露組顯著升高,OR及95%CI分別為1.880(1.038~3.405)(P=0.037),3.446(1.327~8.945)(P=0.011)和6.817(1.698~27.366)(P=0.007).結(jié)論胎兒期和兒童期饑荒暴露與女性成年后出現(xiàn)白蛋白尿的風(fēng)險(xiǎn)存在顯著的相關(guān)性,且這種相關(guān)性是獨(dú)立于血糖、血壓、BMI、吸煙和體力活動(dòng)水平而獨(dú)立存在的.

Abstract:: Objective To investigate whether exposure to the Chinese famine during fetal life and childhood is associated with the risks of microalbuminuria.Methods A total of 4 504 participants born between 1953 and 1964 were included in the study.Famine exposure groups were defined as nonexposed;fetal exposed;and early childhood,or late childhood exposed.Multiple logistic regression models were used to analyze the odds ratio and 95% CI of microalbuminuria associated with exposure to famine,after adjustment for potential confounders,such as age,BMI,smoking status,alcohol consumption,physical activity,fasting glucose as well as systolic blood pressure.Results Female who were exposed to the famine during fetal life,early childhood and late children had a higher risk of microalbuminuria,as compared with nonexposed subjects (odds ratio 1.880 [95% CI 1.038~3.405,P=0.037],3.446[95% CI 1.327~8.945,P=0.011],6.817[95% CI 1.698~27.366,P=0.007],respectively).Conclusion Exposure to the Chinese famine during fetal life or childhood is associated with an increased risk of microalbuminuria in adulthood for female.

更新日期/Last Update: 1900-01-01