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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:

39

期數(shù):

2017年3期

頁碼:

74-76

欄目:

實驗研究

出版日期:

2017-06-15

文章信息/Info

Title:

Influence of β-interferon on recovery of neurological function after acute spinal cord injury in rats

作者:

吳世強[1]; 徐杰[2]; 林文平[1]

福建醫(yī)科大學(xué)第二臨床醫(yī)學(xué)院福建醫(yī)科大學(xué)附屬第二醫(yī)院骨科泉州362000福建省立醫(yī)院骨二科

Author(s):

WU Shi-qiang[1]; XU Jie[2]; LIN Wenping[1]

關(guān)鍵詞:

β-干擾素; 大鼠; 脊髓損傷; 神經(jīng)功能評分

Keywords:

β-interferon; rat; spinal cord injury; neurological function score

分類號:

R651.2

摘要:

目的初步探討β-干擾素對大鼠急性脊髓損傷后神經(jīng)功能恢復(fù)的影響.方法SD成年大鼠40只隨機分成A組(脊髓損傷組)、B組(甲基強的松龍干預(yù)組)、C組(β-干擾素干預(yù)組)、D組(假手術(shù)組)各10只,用改良的Allen裝置撞擊大鼠脊髓胸9~10節(jié)段建立脊髓損傷模型,術(shù)后各組予相應(yīng)干預(yù)處理.采用BBB評分、改良Tarlov評分和斜板實驗方法觀察大鼠行為學(xué)改變情況,于術(shù)后第1、3、7、14和21天對大鼠急性脊髓損傷后不同時段的脊髓神經(jīng)功能進行評分.結(jié)果大鼠急性脊髓損傷后BBB評分、改良Tarlov評分和斜板實驗分值均近0,隨著時間進展評分逐漸升高,B、C組升高明顯,干預(yù)治療的B、C組與A組相比7d內(nèi)無顯著變化(P>0.05),14d時有顯著變化(P<0.05);但B組與C組比較無顯著變化(P>0.05).結(jié)論β-干擾素應(yīng)用有利于大鼠急性脊髓損傷后神經(jīng)功能恢復(fù),其作用機制需要進一步研究.

Abstract:

Objective To explore the effect of β-interferon on neurological function recovery after acute spinal cord injury in rats.Methods Forty adult SD rats were randomly divided into four groups:group A (spinal cord injury group),group B (methylprednisolone intervention group),group C (intervention with β-interferon);Group D (sham operation group).The acute spinal cord injury model of rats was established by impinging on the thoracic spinal cord segment 9-10 with modified Allen device.The rats were treated with BBB,modified Tarlov score and inclined plate test.Changes of neurological function were evaluated at 1st,3rd,7th,14th and 21th day postoperatively,and the neurological function of the spinal cord was evaluated at different time points after acute spinal cord injury in rats.Results BBB score,modified Tarlov score and ramp plate test scores were nearly 0 in acute spinal cord injury rats.The scores of B and C increased significantly with the time of treatment.There was no significant difference (P>0.05) between the B and C groups and the spinal cord injury control A group within 7 days (P> 0.05),but there was significant difference at 14th day(P<0.05).But there was no significant difference between group B and group C (P>0.05).Conclusion Interventional therapy with β-interferon after acute spinal cord injury in rats is beneficial to the recovery of neurological function.The mechanism of action need further study.

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更新日期/Last Update: 1900-01-01