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大鼠脊髓損傷進(jìn)行自體神經(jīng)移植后的光鏡觀察分析

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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

Title:: Observation of light microscope after autogenous nerve transplantation on spinal cord injured in rats

作者:: 林瀟哲[1]; 劉文革[2]; 陳上衛(wèi)[1]; 徐光輝[1]; 福建衛(wèi)生職業(yè)技術(shù)學(xué)院附屬醫(yī)院福建省級機(jī)關(guān)醫(yī)院骨科福州350001福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院骨科

Keywords:: spinal cord injury; autologous nerve; transplantation; pathology; rat

摘要:: 目的探討大鼠脊髓損傷后使用自體腓腸神經(jīng)組織移植修復(fù)后的病理變化.方法將實驗動物分為自體腓腸神經(jīng)移植組和非移植組各18例.兩組利用改良Allen撞擊方法建立脊髓損傷模型,損傷4周后移植組利用自體腓腸神經(jīng)移植修復(fù)脊髓損傷段,非移植組僅暴露切口不做處理.分別于術(shù)后4、6、8周在光鏡下觀察脊髓損傷段及移植腓腸神經(jīng)再生狀況.結(jié)果非移植組脊髓損傷段退化、變性,可見囊性空腔及瘢痕.移植組術(shù)后4周損傷區(qū)脊髓與移植物呈非緊密結(jié)合;術(shù)后6周融合良好;術(shù)后8周見再生神經(jīng)纖維,通過損傷段與遠(yuǎn)端脊髓有機(jī)融合.與非移植組各組相比的差異有統(tǒng)計學(xué)意義(P<0.01).結(jié)論自體神經(jīng)移植修復(fù)大鼠脊髓損傷移植物不僅良好存活,而且促進(jìn)受損脊髓軸突再生.

Abstract:: Objective To investigate the pathological changes of autogenous sural nerve transplantation on spinal cord injured in rats.Methods The animals were divided into two groups.All of them used modified Allen impact method to establish model of spinal cord injury.After four weeks,the transplantation group used autologous sural nerve graft to repair spinal cord injury period,the non-transplantation group only exposed incision without treatment.In the 4,6 and 8 weeks after operation,observation of regeneration of the injured spinal cord in the light microscope was performed.Results In the non-transplantation group,spinal cord represented degeneration,cystic cavity and cicatrix were found.In the transplantation group,most of peripheral nerve survived,and was fused with the spinal tissue with time lapse after transplantation.Compared with the non-transplantation group,there were significant differences (P<0.01).Conclusion After spinal cord injury,autologous nerve graft is repaired and survived well and can promote the recovery of spinal cord injury.

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更新日期/Last Update: 1900-01-01