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[1]林福成[],林仕芳[],朱紀(jì)婷[].神經(jīng)元表面抗體相關(guān)腦炎5例臨床分析[J].福建醫(yī)藥雜志,2017,39(3):32-35.
　LIN Fucheng[],LIN Shifang[],ZHU Jiting[].Neuronal surface antibody-associated encephalitis:clinical analysis of five cases[J].FUJIAN MEDICAL JOURNAL,2017,39(3):32-35.
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神經(jīng)元表面抗體相關(guān)腦炎5例臨床分析
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
39
期數(shù):
2017年3期
頁(yè)碼:
32-35
欄目:
國(guó)外指南摘譯
出版日期:
2017-06-15

文章信息/Info

Title:
Neuronal surface antibody-associated encephalitis:clinical analysis of five cases
作者:
林福成[1]; 林仕芳[2]; 朱紀(jì)婷[2]
福建省莆田市涵江醫(yī)院神經(jīng)內(nèi)科莆田351111福建醫(yī)科大學(xué)附屬第一醫(yī)院神經(jīng)內(nèi)科
Author(s):
LIN Fucheng[1]; LIN Shifang[2]; ZHU Jiting[2]
關(guān)鍵詞:
神經(jīng)元表面抗體; 腦炎; 臨床表現(xiàn); 治療
Keywords:
neuronal surface antibody; encephalitis; clinical manifestations; treatment
分類號(hào):
R512.3
摘要:
目的分析兩種神經(jīng)元表面抗體相關(guān)腦炎的臨床表現(xiàn)、輔助檢查及治療效果,提高對(duì)本病的認(rèn)識(shí).方法對(duì)2015年6月至2016年8月在福建醫(yī)科大學(xué)附屬第一醫(yī)院神經(jīng)內(nèi)科就診的4例抗N-甲基-D-天冬氨酸(NMDA)受體腦炎和1例抗α-氨基-3-羥基-5-甲基-4-異惡唑丙酸(AMPA)2受體腦炎患者的臨床表現(xiàn)、輔助檢查、治療方案及療效進(jìn)行回顧性分析.結(jié)果5例患者均有精神行為異常、癲癇發(fā)作、記憶障礙.4例抗NMDA受體腦炎患者腦脊液抗NMDA受體抗體3例陽(yáng)性、1例未查,血清抗NMDA受體抗體3例陽(yáng)性、1例可疑陽(yáng)性;2例發(fā)現(xiàn)卵巢畸胎瘤.1例抗AMPA2受體腦炎患者腦脊液及血清抗AMPA2受體抗體均陽(yáng)性.經(jīng)治療后2例基本治愈,3例明顯好轉(zhuǎn).結(jié)論對(duì)新發(fā)精神行為異常伴癲癇發(fā)作、記憶障礙等疑似腦炎患者,應(yīng)盡早行自身免疫性腦炎抗體檢測(cè),及時(shí)診斷和治療以改善本病的預(yù)后.
Abstract:
Objective To summarize the clinical manifestations,auxiliary examinations and prognosis of two types of neuronal surface antibody-associated encephalitis.Methods The clinical manifestations,auxiliary examinations,treatments and therapeutic effects of four cases of anti-N-methyl-D-aspartate(NMDA) receptor encephalitis and one case of anti-α-amino-3-hydroxy-5-methlyl-4-isoxazole propionic acid(AMPA)2 receptor encephalitis collected from the First Affiliated Hospital of Fujian Medical University in June 2015 to August 2016 were retrospectively analyzed.Results Five patients all showed mental disorders,seizures,and memory impairments.In four anti-NMDA receptor encephalitis cases,the antibody in cerebrospinal fluid were positive in three cases and was without check in the other one;serum anti-NMDA receptor antibody were positive in three cases and was suspicious positive in the other one.Ovarian teratomas were found in two cases.In the anti-AMPA2 receptor encephalitis case,the antibody were positive in both cerebrospinal fluid and serum samples.Two cases were cured after treatments,and the other three cases were significantly better.Conclusion In cases of patients with mental disorders,seizures and memory disorders,autoimmune encephalitis antibodies should be tested as soon as possible,timely diagnosis and treatment will improve outcome of neuronal surface antibody-associated encephalitis.
更新日期/Last Update: 1900-01-01